Cure My Disease

Don't miss your cure!

 Log in / Sign up

Laser and gel combo aims to boost skin healing

NCT ID NCT05411484

Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study looks at whether using a laser followed by a gel containing doxycycline (NanoDOX) can help medicine reach deeper into the skin and improve wound healing. About 12 healthy adults will receive the laser treatment and gel on small skin areas, and then have biopsies to measure how much medicine gets into the skin. The goal is to see if this combination works better than laser alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

10 people

The number who actually took part.

Started

Nov 2023

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subject must be able and willing to provide written informed consent and comply with the requirements of the study protocol; * Subject must be able to read and understand English; * Any gender and any Fitzpatrick skin type; * Age equal to or greater than 18 years old; * Willing to sun protect treated area (sunscreen or cover the area with clothes) for the duration of enrollment in the study and 1 year after treatment. * Subjects must be willing to undergo skin biopsies Exclusion Criteria: * Participation in another investigational drug or device clinical trial in the past 30 days; * Are pregnant or lactating; * History of allergic reaction to topical or local anesthesia; * History of allergic reaction to Doxycycline or other tetracyclines; * Regular intake of high doses of anti-inflammatory drugs (aspirin \>81 mg/day, ibuprofen, corticosteroids, etc.) , immunosuppressive drugs or biologics; * Clinically significant abnormal findings or conditions which might, in the opinion of the Investigator, interfere with study evaluations or pose a risk to subject safety during the study; * Laser treatment in past six months; History of poor wound healing; * History of keloids; History of extreme photosensitivity; * History of severe hyperpigmentation; History of tattoos on thighs.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Wounds and injury are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Wounds and injury

Contacts and locations

Locations

  • MGH Clinical Unit for Research Trials And Outcome

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.