Proton vs. X-Ray: which prostate cancer treatment is kinder?

NCT ID NCT01617161

Ongoing Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of radiation therapy for low- or intermediate-risk prostate cancer: proton therapy (PBT) and intensity-modulated radiation therapy (IMRT). Both are thought to be equally effective at treating the cancer, but it's unclear which causes fewer side effects like bowel, urinary, or erectile problems. About 450 men are participating to see which treatment better preserves quality of life two years after treatment.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

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Locations

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Mass General/North Shore Cancer Center

Danvers, Massachusetts, 01923, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Northwestern Medicine Chicago Proton Center

Chicago, Illinois, 60190, United States
Princeton ProCure Proton Therapy Center

Somerset, New Jersey, 08873, United States
Provision Proton Therapy Center

Knoxville, Tennessee, 37909, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
University Hospital of Cleveland

Cleveland, Ohio, 44106, United States
University of Florida Health Proton Therapy Institute

Jacksonville, Florida, 32206, United States
University of Maryland Medical Center

College Park, Maryland, 20742, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
Washington University

St Louis, Missouri, 63110, United States

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