Healthy volunteers breathe high-dose nitric oxide to test safety limits

NCT ID NCT05612074

Ongoing Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial at Massachusetts General Hospital is studying how the body processes high doses of inhaled nitric oxide in 10 healthy adults aged 18–64. Participants breathe the gas for 30 minutes, three times a day, while researchers measure methemoglobin levels—a byproduct that can affect oxygen delivery. The goal is to understand how quickly methemoglobin forms and clears, which could inform safer use of nitric oxide in future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inhaled nitric oxide gas
What this could lead to: If successful, this study could help design safer high-dose nitric oxide therapies for conditions like lung or heart disease.
What could go wrong: This is a very small, early-phase safety study in healthy volunteers, not patients. It does not test any treatment benefit, so results may not apply to sick individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY SUBJECTS

Contacts and locations

Locations

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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