Healthy volunteers breathe high-dose nitric oxide to test safety limits
NCT ID NCT05612074
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial at Massachusetts General Hospital is studying how the body processes high doses of inhaled nitric oxide in 10 healthy adults aged 18–64. Participants breathe the gas for 30 minutes, three times a day, while researchers measure methemoglobin levels—a byproduct that can affect oxygen delivery. The goal is to understand how quickly methemoglobin forms and clears, which could inform safer use of nitric oxide in future treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Inhaled nitric oxide gas
What this could lead to
If successful, this study could help design safer high-dose nitric oxide therapies for conditions like lung or heart disease.
What could go wrong
This is a very small, early-phase safety study in healthy volunteers, not patients. It does not test any treatment benefit, so results may not apply to sick individuals.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States