HEALTHY SUBJECTS

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The main goals are to check safety, how the body processes the drug, and to get an early look at whether it helps with weight loss or blood suga…

This early-phase study tests the safety and radiation of Radiocaine, a new radioactive tracer for PET scans. Six healthy adult volunteers will receive an injection and be monitored for side effects and radiation exposure. The goal is to see if Radiocaine can safely light up nerve…

This study is testing a new imaging agent called [18F]FT8 to see if it can help doctors better see and diagnose amyloidosis, a disease where abnormal proteins build up in organs like the heart. The study will involve 20 patients with amyloidosis and 5 healthy volunteers. Research…

This early-stage trial tests whether a vaginal film containing an anti-sperm antibody (KB15A) is safe for healthy women. Twenty-four participants will receive either the active film or a placebo, first as single doses and then daily for 14 days. Researchers will monitor for side …

This early-stage study tests a single dose of an experimental drug called GTX-B001 in healthy people and those with chronic inducible urticaria—a condition where cold or scratching causes painful hives. The main goal is to check safety and how the body handles the drug. About 72 …

This study tests whether new CT imaging methods that use less radiation can produce pictures as clear as standard CT scans. About 215 healthy adults scheduled for a chest, abdomen, and pelvis CT will get one extra low-radiation scan. Researchers will compare image quality between…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study looks at bladder and bowel problems in children aged 5 to 12 with intellectual disabilities and compares them to typically developing children. Researchers want to understand how these issues affect the child's daily activities and family quality of life. The goal is t…

This study uses MRI scans to measure the electrical properties of the head, neck, and torso in 120 healthy volunteers across three age groups: children (6-12), adults (20-40), and seniors (70+). The goal is to build a detailed database of how these properties change with age, whi…

This early-stage trial is testing a new drug called SYH2061 in 40 healthy adults aged 18 to 55. The main goal is to see if it is safe and how the body handles it. Participants receive either the drug or a placebo by injection, and researchers monitor for side effects and measure …

This study checks if a new version of a drug (YHP2511) is absorbed into the body the same way as the original (YHP2511A). About 60 healthy adults aged 19 to 55 will take a single dose of each version on separate days. The goal is to see if the two versions are bioequivalent, mean…

This study tests a new brain scanning method called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. If successful, fNIRS could…

This early-phase study tests the safety and how the body handles a new injection called HEC-007. It involves 126 healthy adults and overweight or obese individuals. Researchers will monitor side effects, measure drug levels in the blood, and check changes in weight and other heal…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study aims to improve MRI scans by testing optimized acquisition sequences. Researchers will compare image quality and comfort between standard and new methods in 720 healthy volunteers and patients. The goal is to make MRI exams faster, clearer, and less stressful.

This early-phase trial tests a new drug called SOB100, which uses tiny particles called exosomes to target a protein named HLA-G. The study involves 15 healthy adults to check if the drug is safe and how the body processes it. No treatment benefit is expected; the goal is to gath…

This observational study is testing whether a noninvasive finger imaging device can detect and evaluate two types of heart valve disease: aortic regurgitation and aortic stenosis. Researchers will record arterial waveforms from participants' fingers and see if the patterns can di…

This study looks at how the temperature of your muscles changes the way they appear on an ultrasound. Researchers will heat a leg muscle, then take ultrasound images as it cools down. The goal is to make muscle ultrasound a more reliable tool for diagnosing conditions. 30 healthy…

This study looks at how a new drug called HDM1002 interacts with five common medications (metformin, empagliflozin, midazolam, valsartan, and warfarin) in overweight or obese adults. About 111 healthy participants aged 18-45 with a BMI between 24 and 35 will take these drugs sepa…

This early-stage trial is testing a new drug called BEAM-103, a monoclonal antibody, in 30 healthy adults aged 18 to 55. Participants receive a single intravenous dose of either BEAM-103 or a placebo and are monitored for up to 4 months. The main goal is to check the drug's safet…

This observational study will compare nasal immune responses to respiratory viruses like SARS-CoV-2 in 40 adults, including immunocompromised patients and healthy volunteers. Researchers aim to understand how underlying conditions and treatments affect immune cell activity in the…

This study looks at people who carry genetic changes linked to Leber Hereditary Optic Neuropathy (LHON) but still have normal vision. Researchers want to see if certain chemicals in the blood and tears can signal early nerve damage in the eye, before vision loss occurs. The goal …

This study tests whether offering a $25 gift card encourages older adults from diverse backgrounds to join an Alzheimer's prevention registry. Researchers will recruit 400 people aged 50+ at community events, comparing the gift card to a non-cash gift. The goal is to see if small…

This study tests a device called the INTERCEPT Blood System that treats red blood cells to kill germs. Researchers want to see if treated red blood cells survive as well as untreated ones after 35 days of storage. About 70 healthy adults will donate blood, have it treated or not,…

This early-stage study tests whether a new drug, CM559, is safe and how the body processes it. About 40 healthy men will receive either the drug or a placebo. The goal is to check for side effects and understand how the drug behaves, not to treat any disease.