HEALTHY SUBJECTS

This is the first time a new drug called BGB-45035 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will first give the drug to healthy volunteers at different doses. Later, a small group of adults with itchy skin conditi…

This is an early-stage study to test the safety and how the body processes a new drug called TLC 6740. It will first be given to healthy volunteers to check for side effects. Later, it will be tested in people with obesity, some of whom also have type 2 diabetes, to see if it mig…

This is the first study in people to test the safety of a new drug called GTX-B001. It will be given as a single dose to 48 healthy volunteers and 24 people with chronic hives triggered by cold or scratching. The main goal is to see how safe the drug is and how the body processes…

This study is testing a new type of PET/CT scan that uses a special tracer called [18F]FT8. The goal is to see if this scan can better detect and diagnose a serious heart condition called AL amyloidosis, where abnormal proteins build up in the heart. Researchers will compare the …

This study is testing a new, noninvasive way to detect and evaluate heart valve diseases. Researchers want to see if a simple scan of a person's finger can accurately capture their pulse wave and reveal problems like aortic regurgitation or stenosis. The study will compare scans …

This early-stage study is testing the safety of a new type of vaginal contraceptive film called KB15A. The film contains an antibody designed to trap sperm to prevent pregnancy. Researchers will give the film to 24 healthy women to check for side effects and see how the body abso…

This study is testing whether offering a small $25 payment encourages more people from diverse backgrounds to join an online Alzheimer's prevention research registry. Researchers will recruit 400 adults aged 50+ at community events and markets, comparing the $25 incentive to a fr…

This study aims to understand how genetic immune system problems affect oral health, particularly gum disease. Researchers will compare people with immune disorders, those with severe gum disease, and healthy volunteers by collecting samples like saliva, plaque, and blood. The go…

This is an early-stage study to test the safety of a new drug called BEAM-103 in healthy people. Researchers will give single, increasing doses to small groups of volunteers to see how their bodies react and process the drug. The main goal is to find a safe dose range for future …

This study is testing whether new CT scan methods that use less radiation can produce images that are just as good as traditional CT scans. Researchers are enrolling adults who are already scheduled for chest, abdomen, or pelvis CT scans. During their regular scan appointment, pa…

This study aims to understand how the temperature of a muscle changes what doctors see on an ultrasound image. Researchers will heat and then cool the thigh muscles of 30 healthy volunteers while taking ultrasound scans. The goal is to make muscle ultrasound a more reliable tool …

This study aims to test new settings for MRI machines to see if they can produce clearer images while making the scanning process faster and more comfortable for patients. Researchers will enroll 720 healthy volunteers and patients needing routine MRI scans to compare the new set…

This early-stage study aims to understand how a new investigational drug for weight management, called HDM1002, interacts with five common medications (including metformin for diabetes and warfarin for blood thinning) when taken together. It will enroll 111 overweight or obese bu…

This study aims to find early warning signs for a genetic eye disease called Leber hereditary optic neuropathy (LHON). Researchers will study 90 healthy people who carry a gene for LHON but haven't lost vision yet. They will analyze blood, tears, and eye scans to look for chemica…

This study aims to better understand the bladder and bowel problems that children with intellectual disabilities often face, and how these issues affect their daily activities and quality of life. Researchers will compare 100 children with intellectual disabilities to typically d…

This study aims to see if a special treatment for donated red blood cells affects how long they last in the body. Healthy volunteers will have some of their own blood drawn, treated or not, stored, and then returned to them with a safe radioactive tag so researchers can track the…

This study aims to understand how the immune system in the nose responds to respiratory viruses like COVID-19. Researchers will compare 40 immunocompromised patients (such as transplant recipients) with healthy volunteers. The goal is to learn how medical conditions and treatment…

This is a very early, first-in-human study to check if a new type of drug called SOB100 is safe and how it moves through the body. SOB100 uses tiny natural particles called exosomes, designed to target a specific protein. The study will enroll 15 healthy volunteers to receive inc…

This early-stage study is testing a new PET scan method that aims to measure both blood flow and how much sugar tissues use from a single injection. Researchers want to see if this works as well as using two separate scans. The goal is to create a simpler tool to help doctors und…

This is an early safety study testing a new drug called CM559 in healthy male volunteers. Researchers will give different doses to 40 participants to check for side effects and see how the body processes the drug. The main goal is to determine if the drug is safe enough for furth…