HEALTHY SUBJECTS

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The main goals are to check safety, how the drug moves through the body, and early signs of effectiveness. Up to 564 participants will take sing…

This early-stage study tests a new drug called BGB-45035 for safety and how the body processes it. First, healthy volunteers receive single or multiple doses. Then, people with autoimmune skin diseases like atopic dermatitis (eczema) or prurigo nodularis receive the drug to check…

This early-phase study tests the safety and radiation levels of a new imaging agent called Radiocaine in 6 healthy adults. The tracer is designed to light up sodium channels in the body during PET scans, which could help diagnose nerve-related conditions in the future. The main g…

This study is testing a new radioactive tracer called [18F]FT8 for PET/CT scans to see if it can safely and clearly show amyloid deposits in the heart and other organs. Researchers will compare the new scan with standard tests like echocardiograms and MRIs. The study involves 20 …

This study tests a new, noninvasive finger imaging device to see if it can detect and tell apart two types of heart valve disease: aortic regurgitation and aortic stenosis. About 15 adults—including healthy volunteers and those with known valve disease—will place a finger in the …

This early-stage study tests whether a vaginal film containing an anti-sperm antibody is safe for healthy women aged 18 to 45. Participants will use the film either once or daily for two weeks. The goal is to check for side effects and see how the antibody spreads in the body.

This early-stage study tests a single dose of a new drug, GTX-B001, for safety. First, healthy volunteers receive the drug to check for side effects. Then, people with chronic inducible urticaria (hives triggered by cold or pressure) receive it to see if it helps. The goal is to …

This early-stage study tests the safety of a new drug, BEAM-103, in 30 healthy adults aged 18 to 55. Participants receive one intravenous dose of either BEAM-103 or a placebo and are monitored for up to 4 months. The goal is to see if the drug is safe and how the body processes i…

This observational study aims to understand how the immune system in the nose responds to respiratory viruses like SARS-CoV-2 in people with weakened immune systems compared to healthy volunteers. Researchers will enroll 40 adults aged 18 to 90, including those who are immunocomp…

This study looks at bladder and bowel problems in children aged 5 to 12 with intellectual disabilities, and how these issues affect their participation in daily activities and their family's quality of life. Researchers will compare 100 children with intellectual disabilities to …

This early-stage study tests a new drug, CM559, in 40 healthy men to see if it is safe and how the body handles it. Participants receive a single dose of the drug or a placebo. The study does not aim to treat any disease, but to gather important safety information for future rese…

This early-phase study at UC Davis tests whether a single PET tracer (FDG) can measure both blood flow and sugar metabolism in the heart at the same time. Researchers will compare FDG results with a standard flow-only tracer in 60 healthy adults and people with heart disease. The…

This early-stage study tests a new drug called SOB100, which uses tiny particles called exosomes to target a protein named HLA-G. The goal is to see if it is safe and how the body processes it in 15 healthy adults. No treatment is given — this is purely a safety and dosing study.…

This study aims to improve the quality of MRI images while making the exam more comfortable for patients. Researchers will test new scanning sequences in 720 healthy volunteers and patients. The goal is to see if these optimized sequences produce clearer pictures without increasi…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from people with genetic immune defects, healthy people with gum disease, and healthy people without gum disease…

This study looks at how a new drug called HDM1002 interacts with five common medicines (metformin, empagliflozin, midazolam, valsartan, and warfarin) in overweight or obese Chinese adults aged 18-45. About 111 healthy volunteers will take these drugs separately and together to me…

This study tests whether offering a small $25 financial reward helps recruit a more diverse group of older adults into the Alzheimer's Prevention Trial Webstudy, an online registry that tracks memory concerns. Researchers will compare this to giving out reusable grocery bags at c…

This early-phase study tests the safety and how the body processes a new injection called HEC-007. It involves 126 healthy adults and overweight or obese volunteers. The goal is to check for side effects and measure drug levels, not to treat any disease.

This study looks at how muscle temperature changes the look of ultrasound images. Researchers will heat and then cool the thigh muscles of 30 healthy adults, taking ultrasound pictures and temperature readings throughout. The goal is to understand this effect so doctors can use u…

This study looks at people who carry gene changes linked to Leber hereditary optic neuropathy (LHON) but still have normal vision. Researchers want to see if certain chemicals in the blood and tears can show early nerve damage in the eye, before vision gets worse. About 90 partic…

This study aims to see if new CT scan methods that use less radiation can create pictures just as clear as traditional CT scans. Researchers will enroll 215 adults who already need a CT scan of their chest, abdomen, and pelvis. During their scheduled scan, one extra low-radiation…

This study tests a new brain scanning method called fNIRS to see if it can predict how unconscious patients with severe stroke or brain injury will recover. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. The goal is to find a sim…

This study aims to see if a new blood processing system can safely preserve red blood cells for transfusion as well as the current standard method. Healthy volunteers will donate their own blood, which will be stored for 35 days, processed with either the new or standard system, …