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Scientists probe nerve signals to give prosthetics a sense of touch

NCT ID NCT07691957

Knowledge-focused Sponsor: Azienda Ospedaliero, Universitaria Pisana Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This experimental study investigates how the median nerve encodes touch sensations in healthy volunteers and people with upper-limb amputations. Researchers use a minimally invasive technique called microneurography to record nerve activity and deliver tiny electrical pulses to evoke near-natural feelings. Participants report what they perceive, helping scientists understand how to restore realistic touch in prosthetic limbs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Microneurography and intraneural microstimulation (procedures)
What this could lead to
If successful, this research could pave the way for advanced prosthetic limbs that provide realistic touch sensations, greatly improving quality of life for amputees.
What could go wrong
This is an early-stage experimental study focused on understanding nerve signals, not a treatment. The techniques are invasive and may not translate into practical prosthetics.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Healthy participants * Age between 18-60 years, of any sex * Signed informed consent * No neurological diseases * Presence of both intact upper limbs * Normal language, visuospatial, and general intellectual abilities, assessed using the Wechsler Adult Intelligence Scale-Revised (WAIS-R) (Appendix 1) Amputee participants * Age between 18-60 years, of any sex * Signed informed consent * Upper-limb amputation (transradial or hand amputation) * Stable amputation for at least one year * Normal language, visuospatial, and general intellectual abilities, assessed using the Wechsler Adult Intelligence Scale-Revised (WAIS-R) (Appendix 1) * Evidence of residual peripheral nerve function in the stump, based on nerve conduction studies as documented in clinical records Exclusion Criteria: Healthy participants * Conditions affecting perceptual abilities * Inability to provide informed consent * Pregnancy or breastfeeding (self-reported) * Clinical conditions that, in the judgment of the investigator responsible for recruitment, may interfere with microneurography, microstimulation, and EEG procedures * Current or past substance abuse * Brain injury with residual motor impairment * Depression * Presence of neurological or musculoskeletal disorders * Diabetes mellitus * Current or previous dermatological conditions * Morphological nerve abnormalities, as indicated by ultrasound or MRI findings in clinical records * Upper-limb amputation Amputee participants * Psychological and/or cognitive disorders * Inability to provide informed consent * Pregnancy or breastfeeding (self-reported) * Clinical conditions that, in the judgment of the investigator responsible for recruitment, may interfere with microneurography, microstimulation, and EEG procedures * Current or past substance abuse * Brain injury with residual motor impairment * Depression * Presence of neurological or musculoskeletal disorders * Diabetes mellitus * Current or previous dermatological conditions * Morphological nerve abnormalities, as indicated by ultrasound or MRI findings in clinical records * Bilateral upper-limb amputation

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy subjects Upper limb amputation

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

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Contacts and locations

Locations

  • Laboratorio Congiunto di Microneurografia e Microneurostimolazione

    RECRUITING

    Pisa, Pisa, 56127, Italy

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