HEALTHY SUBJECTS

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This completed Phase 1 trial tested whether a new biosimilar insulin called Insulex® R works similarly to the standard Humulin® R. Forty healthy adults received a single injection of each insulin in a crossover design. Researchers measured how the body absorbed the insulin and ho…

This early-stage study tested a new biologic drug called AZD7798 in 112 people, including healthy volunteers and patients with Crohn's disease. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or repeated doses and monitored fo…

This early-stage trial tested an experimental drug called SHR-4597, given as an inhaled powder, in 62 healthy volunteers and people with asthma. The main goal was to see if it is safe and tolerable. The study gave single doses to healthy people and multiple doses over several day…

This study tested whether mindfulness meditation training can improve quality of life and brain activity in people with refractory epilepsy (seizures that don't respond to drugs). 37 participants (patients and healthy volunteers) took part in meditation sessions. The main goal wa…

This early-stage study tested a single injection of AYP-101 in 26 healthy adults to see if it safely reduces fat under the chin. Participants were aged 19 to 65 with a BMI under 35. The main goal was to check for side effects and how the drug moves through the body.

This study tested whether a short, 3-minute neck stretch could lower blood pressure in 25 healthy adults. Participants did a gentle stretch on one side of the neck, and researchers measured blood pressure, tissue stiffness, and heart rate changes. The goal was to see if stretchin…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This early-stage study tested a single injection of ebronucimab in 230 healthy Chinese men to see if different production methods change how the drug behaves in the body. The main goal was to measure drug levels in the blood and check for side effects. This trial does not aim to …

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study looked at whether adding dry needling, acupuncture, or sham needling to a muscle release technique improves knee range of motion, balance, and jump height in active men aged 18-28 with tight hamstrings and quadriceps. Sixty-five participants were split into four groups…

This study tested whether a special class on the science of pain (pain neuroscience education) could improve how physiotherapy students think about and treat pain. 120 healthy students took part. The goal was to see if their knowledge, attitudes, and beliefs about pain changed af…

This early-phase trial tested a single injection of a new drug called SHR-3167 alongside standard insulin glargine in 24 healthy men. The goal was to compare how the drugs affect blood sugar and how the body processes them. The study focused on safety and basic drug behavior, not…

This study used wireless EEG headsets to watch brain activity in 45 healthy adults as they were put under anesthesia with propofol. Researchers focused on slow-wave brain signals to understand how and when people lose consciousness. The goal is to learn more about the brain's res…

This early-phase trial tested the safety and tolerability of a new drug called ICP-332 in 24 healthy adults. Participants received either the drug or a placebo in multiple doses. The study is now complete and focused on monitoring side effects and changes in vital signs, ECG, and…

This early-phase trial tested the safety and how the body processes the drug MT-7117 (dersimelagon) in 40 healthy Chinese adults aged 18 to 55. Participants received either the drug or a placebo, and researchers measured drug levels in the blood and monitored for side effects. Th…

This study measured how much of the drug cenerimod gets into the blood after swallowing a tablet. Six healthy men took one pill, then received a tiny radioactive version of the drug through a vein. They stayed at the clinic for 4 days and returned for checkups over 3 months. The …

This study aimed to make MRI scans clearer and more reliable. Researchers tested new imaging methods on 1,807 healthy adults to improve picture quality and reduce blurring. No treatment or medication was given—the goal was simply to gather knowledge to help future patients.

This study checked whether a single pill containing three cholesterol-lowering medicines (bempedoic acid, ezetimibe, and atorvastatin) works the same in the body as taking the three drugs separately. It involved 58 healthy adults aged 18 to 60. The goal was to see if the combinat…

This early-stage trial tested the safety and how the body handles CKD-508, a new drug, in 44 healthy adults. Participants received either the drug or a placebo once daily. The study measured side effects, drug levels in the blood, and changes in cholesterol-related markers. Since…

This study looked at whether pea protein supplements work as well as whey protein for building muscle and strength in healthy young adults. 34 people took either pea or whey protein twice a day for 8 weeks while doing a resistance training program. Researchers measured changes in…

This study aimed to create a visual guide to skin aging by taking detailed 3D images of collagen in the skin of 250 healthy women aged 20 to 75. Using a special camera called LC-OCT, researchers measured collagen density and structure without any needles or surgery. No treatments…

This early-stage trial tested the safety and tolerability of TJ0113 capsules in 130 healthy adults. Participants received either single or multiple doses of the drug or a placebo, and some took it after a high-fat meal. The study measured side effects and how the drug moves throu…

This study looked at whether platelets treated with the INTERCEPT system and stored for 5 days work as well as fresh platelets. 40 healthy adults donated platelets, which were treated and stored, then compared to fresh platelets. The goal was to see how many platelets survived af…

This study tested whether a single pill containing three cholesterol-lowering drugs (bempedoic acid, ezetimibe, and atorvastatin) works the same as taking them separately. 58 healthy adults participated in a crossover trial where they received both forms. The goal was to see if t…

This early-stage trial tested the safety and tolerability of a new drug, UP-818-CC, in 73 healthy Chinese volunteers. Participants received either a single dose or multiple daily doses of the drug or a placebo. The main goal was to check for side effects and measure how the drug …

This study tested whether doing 30 squats on an unstable surface (like a wobble board) improves balance and coordination more than squats on a stable floor. 42 healthy adults aged 18-35 participated. Researchers measured postural stability, leg coordination, and dynamic balance r…

This study tested the safety and skin-friendliness of new adhesive baseplates for the UNEEG Episight recorder, a device that records brain waves. Thirty-four healthy adults wore different baseplates behind their ears for about 17-18 days each. Researchers measured skin health and…

This early-stage study tested the safety of a new drug called TISA-818 in 49 healthy adults. Participants received either the drug or a placebo as a single shot or daily shots for a week. The goal was to check for side effects and how the drug moves through the body, not to treat…

This study looked at 70 people—some with primary myelofibrosis and some healthy—to understand how certain immune cells called MDSCs fuel inflammation in this rare bone marrow disease. Researchers also checked how these cells change with treatment and whether they help form new bl…

This study checked if a single pill containing three cholesterol-lowering drugs works the same as taking them separately. It involved 58 healthy adults aged 18 to 60. The goal was to see if the combination pill is absorbed similarly, not to treat any disease.

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This early-stage study tested the safety and how the body handles a new drug, LV232, in 81 healthy Chinese volunteers. Participants received either the drug or a placebo to check for side effects and measure drug levels in the blood. The goal was to gather safety information, not…

This study tested whether a single pill containing three cholesterol-lowering drugs (bempedoic acid, ezetimibe, and rosuvastatin) works the same as taking them separately. Fifty-eight healthy adults each received both the combination pill and the individual pills at different tim…

This early-stage trial tested a new drug, M6229, in 15 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a continuous 5-day infusion. The study is complete and focused on safety and drug levels, not on treatin…

This early-stage study tested the safety and how the body handles a new drug called ABSK061 in 40 healthy adults aged 18 to 45. Participants took the drug as minitablets, either alone or with soft foods, to see if food affects absorption. The goal was to gather basic safety and p…

This study looked at how safe two experimental antibiotics (VNRX-7145 and ceftibuten) are when given alone or together. It involved 53 healthy adults aged 18 to 55. The goal was to measure how the drugs move through the body and check for side effects, not to treat any illness.

This early-stage study tested the safety of a new drug called VNRX-5024 in 36 healthy adults aged 18-55. Participants received either the drug or a placebo, first as a single dose and then daily for 10 days. The main goal was to check for side effects and measure how the drug mov…

This study checked if two different versions of an antibiotic (amoxicillin/clavulanic acid) work the same in the body. 63 healthy adults took a single dose of each drug in a random order. The goal was to see if the levels of drug in the blood were similar enough to consider the d…

This completed Phase 1 trial enrolled 70 healthy adults to compare two tablet formulations of the same drug, DWJ1445 and DWC202506. Participants received a single dose of each in random order, and researchers measured drug levels in the blood to check if the two versions are abso…

This early-stage study tested the safety of a new experimental drug, SUL-238, in 83 healthy adults aged 40 and older. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat …

This early-stage study tested the safety and how the body handles multiple doses of the experimental drug LV232 in 49 healthy Chinese volunteers. Participants received different doses of LV232 or a placebo to check for side effects and measure drug levels in the blood. Since this…

This completed study tested whether a short session of neck stretching or using a massage roller on the neck could improve flexibility not only in the neck but also in the hip. Thirty healthy adults participated, and researchers measured range of motion and tissue stiffness. The …

This early study tested a drug called N-803 in 10 healthy volunteers to see if it could help collect and grow more natural killer cells from their blood. The main goal was to check safety and side effects. The study is already complete, but it does not test whether these cells ca…

This study tested a new wearable ECG sensor called the ZywieZ3 in 45 healthy adults. The sensor was compared to a standard hospital ECG device over one hour, then worn for 10 days to check signal quality and skin adhesion. Researchers also tested how different placements on the c…

This early-stage trial tested the safety and tolerability of multiple intravenous doses of zidebactam, an experimental antibiotic, in 21 healthy adults. Participants received either the drug or a placebo, and researchers monitored for side effects, vital signs, and lab results. T…

This study gave a single dose of a radiolabeled drug called cenerimod to 6 healthy men aged 45-65. The goal was to see how quickly and by what routes (urine, feces, breath) the drug leaves the body. It is a Phase 1 trial with no treatment benefit, purely to gather information for…

This early-stage trial tested a single dose of a new drug called SAR441255 in 48 healthy, lean to overweight adults. The main goal was to check safety and how the body processes the drug. Researchers also looked at effects on blood sugar and insulin levels. This is a first step t…

This early-stage trial in 97 healthy adults checks if cenerimod, an experimental drug, affects heart rhythm (QT interval) and how it interacts with birth control pills and activated charcoal. Participants receive either placebo, low or high dose cenerimod, or a control drug (moxi…

This study looked at whether the time of day changes a person's 'immune age' — a blood-based score that reflects how well the immune system is aging. Researchers took blood samples from 50 healthy adults aged 20 to 69 at three different times (morning, midday, and evening) on the…

This study looked at whether vocal exercises or breathing exercises work better to improve lung function and trunk (core) stability in healthy women aged 18 to 65. Fifty women did six weeks of either vocal or breathing exercises, twice a week for 30 minutes. Researchers measured …

This completed Phase 1 trial tested the drug tolvaptan (7.5mg) in 12 healthy men to see how the body absorbs, processes, and eliminates it. Participants took the tablet eight times over nine days. The study measured drug levels in the blood and checked for side effects, but it wa…

This early-phase study tested a new radioactive tracer called [18F]F13640 in 20 healthy volunteers. The tracer is designed to attach to specific receptors in the brain and be seen on a PET scan. The goal was to validate the imaging method and check how reproducible the results ar…

This completed study gave 22 healthy volunteers a single dose of diazepam, lorazepam, or a placebo, then used brain scans to see how these drugs affect memory and perception. The goal was to understand why lorazepam may impair unconscious memory more than diazepam. The findings c…

This completed study looked at how the prefrontal cortex helps us understand analogies and categories. Researchers used brain scans, EEG, and magnetic stimulation in 130 healthy volunteers and patients with frontotemporal dementia or progressive supranuclear palsy. The goal was t…