Swallow a capsule, detect esophagus disease?

NCT ID NCT02422433

Ongoing Diagnosis Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a special imaging capsule (OFDI) that patients swallow to take detailed pictures of the esophagus. The goal is to see if it can accurately detect Barrett's esophagus, a condition that can lead to cancer. Researchers will compare the capsule's images with standard endoscopy and biopsy results in 130 adults already scheduled for an upper endoscopy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: OFDI capsule (imaging device)
What this could lead to: If successful, this could offer a less invasive way to detect and monitor Barrett's esophagus, potentially reducing the need for traditional endoscopy.
What could go wrong: This is an early feasibility study, not a treatment trial. The device may not be accurate enough to replace standard endoscopy, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Barrett esophagus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT'S ESOPHAGUS

Contacts and locations

Locations

Massachusetts General hospital

Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.