New combo aims to melt fat, save muscle in obesity battle
NCT ID NCT05933499
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) helps people with obesity lose mostly fat while keeping muscle and bone. 63 adults will receive either the combo, tirzepatide alone, or bimagrumab alone for 52 weeks. The goal is to improve body composition and insulin sensitivity without the usual muscle loss seen with weight loss.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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