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Once-Daily pill may sharpen thinking in older kidney transplant patients

NCT ID NCT06751992

Recruiting now Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two anti-rejection drugs in older kidney transplant recipients: a once-daily extended-release version (Envarsus XR) versus the standard twice-daily immediate-release version (Prograf). Researchers will measure changes in thinking, memory, and other cognitive skills over time using standard tests. The goal is to see if the once-daily drug helps preserve or improve brain function better than the twice-daily drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
extended-release tacrolimus (Envarsus XR)
What this could lead to
If it works, this could show that a once-daily anti-rejection drug helps older kidney transplant patients maintain or improve their thinking and memory compared to the standard twice-daily drug.
What could go wrong
This is a small, early-phase study (92 people) looking at cognitive test scores, not major health outcomes. The results may not apply to all kidney transplant patients, and the drug switch might not show a clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

insomnia Tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT RECIPIENTS OLD AGE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • MGH Kidney Transplant Clinic

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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