Experimental drug cocktail targets tough childhood cancers in adults
NCT ID NCT01858168
First seen Jan 10, 2026 · Last updated May 13, 2026 · Updated 15 times
Summary
This early-phase study tested a combination of two drugs, olaparib and temozolomide, in 49 adults with Ewing sarcoma or rhabdomyosarcoma that had come back or spread after standard chemotherapy. The goal was to find the safest dose and see if the combo could shrink tumors. While not a cure, the approach aims to control the disease by blocking cancer cells' ability to repair their DNA.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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St. Jude's Children's Research Hospital
Memphis, Tennessee, 38105, United States
Conditions
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