Could letting blood pressure drop after heart surgery be safer?
NCT ID NCT06476613
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study at Massachusetts General Hospital tests whether allowing a slightly lower blood pressure (MAP above 60 mmHg) after heart surgery is safe and reduces the need for blood-pressure-raising drugs. 80 adults having elective heart surgery are randomly assigned to either this 'permissive hypotension' approach or usual care. The goal is to see if this approach is feasible and to gather data for a larger future trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Permissive hypotension (lower blood pressure target of MAP >60 mmHg)
What this could lead to
If successful, this could pave the way for a larger trial that may change how blood pressure is managed after heart surgery, potentially reducing medication use and hospital stays.
What could go wrong
This is a small pilot study (80 people) testing feasibility, not effectiveness. It may not show clear benefits or could reveal risks like organ damage from low blood pressure.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States