Chill out: skin cooling may ease pain of NF1 treatments
NCT ID NCT06132165
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether cooling the skin before or during laser and injection treatments for neurofibromatosis type 1 (NF1) skin bumps can reduce pain. Thirteen adults with NF1 received four different treatments (two lasers and two injections) on both cooled and non-cooled skin areas. The main goal was to see if cooling made the procedures more tolerable and safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Skin cooling (ice or cold device) applied before or during laser or injection treatments
What this could lead to
If it works, skin cooling could make existing treatments for NF1 skin bumps less painful and more tolerable.
What could go wrong
This is a very small Phase 1 study with only 13 people, so results may not apply to everyone. The cooling might not reduce pain enough to matter.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Wellman Center for Photomedicine
Boston, Massachusetts, 02114, United States