Chill out: skin cooling may ease pain of NF1 treatments

NCT ID NCT06132165

Completed Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether cooling the skin before or during laser and injection treatments for neurofibromatosis type 1 (NF1) skin bumps can reduce pain. Thirteen adults with NF1 received four different treatments (two lasers and two injections) on both cooled and non-cooled skin areas. The main goal was to see if cooling made the procedures more tolerable and safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Skin cooling (ice or cold device) applied before or during laser or injection treatments
What this could lead to: If it works, skin cooling could make existing treatments for NF1 skin bumps less painful and more tolerable.
What could go wrong: This is a very small Phase 1 study with only 13 people, so results may not apply to everyone. The cooling might not reduce pain enough to matter.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neurofibromatosis type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROFIBROMATOSIS 1

Contacts and locations

Locations

Wellman Center for Photomedicine

Boston, Massachusetts, 02114, United States

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