One dose, big hope: antibiotic may stop cholera in kids

NCT ID NCT04326478

Completed Prevention Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests whether giving children a single dose of the antibiotic azithromycin right after a household member tests positive for cholera can prevent them from getting infected. The study enrolls children aged 1 to 15 who share cooking facilities with a cholera patient. Researchers will also check if this approach increases antibiotic-resistant bacteria, which could affect future treatment strategies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a single weight-based dose of the antibiotic azithromycin
What this could lead to: If effective, this could offer a simple way to protect children living with a cholera patient from getting sick, potentially saving lives in outbreak settings.
What could go wrong: This is a phase 2 trial, so results are preliminary. The drug may not prevent infection, and the study also examines whether it increases antibiotic-resistant bacteria, a potential downside.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cholera prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLERA

Contacts and locations

Locations

icddr,b Dhaka hospital

Dhaka, Bangladesh

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