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Cholera vaccine ring strategy tested in bangladesh hotspots

NCT ID NCT07685574

Prevention Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests a targeted approach to stop cholera spread in Dhaka, Bangladesh. When someone tests positive for cholera, their household and nearby neighbors (within about 20–40 meters) are offered an oral cholera vaccine. The goal is to see if this ring vaccination reduces the number of new cholera cases over three years. Around 68,400 people are expected to take part, and researchers will track infections through hospital surveillance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oral cholera vaccine (Cholvax)
What this could lead to
If effective, this targeted vaccination strategy could help control cholera outbreaks in high-risk urban areas, reducing the spread of disease.
What could go wrong
The study is observational in design, not a randomized controlled trial, so results may be influenced by other factors. Vaccine effectiveness may vary by dose and community compliance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 68,400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Index case eligibility Inclusion Criteria: 1. Some to severe dehydrated diarrheal patient 2. Provide signed informed consent form Exclusion criteria: 1\. Resident in a ward already covered by OCV since 2015 Vaccination Eligibility Inclusion Criteria: 1. Aged ≥1 year and non-pregnant 2. Meeting the definition of IHC and NHC 3. Provide signed informed consent form Exclusion criteria: 1. History of taking OCV 2. Currently suffering from diarrhea 3. \< 1 year of age 4. Pregnant women (verbally confirmed) 5. Index case

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Conditions

The condition(s) this trial relates to.

cholera

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cholera Methodology study

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b)

    RECRUITING

    Dhaka, 1212, Bangladesh

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