New combo therapy shows promise for Tough-to-Treat stomach cancer
NCT ID NCT03279237
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested a combination of chemotherapy drugs (FOLFIRINOX plus paclitaxel and carboplatin) along with proton beam radiation before surgery in 25 people with gastroesophageal cancer. The goal was to see if this intense pre-surgery treatment could shrink tumors and be completed safely. The study is complete, but results on how well it worked are still being analyzed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- FOLFIRINOX (a combination of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin) plus paclitaxel, carboplatin, and proton beam radiation
- What this could lead to
- If successful, this approach could improve tumor shrinkage before surgery for gastroesophageal cancer, potentially leading to better outcomes.
- What could go wrong
- This is a small, early-phase pilot study (Phase 1) with only 25 participants, so results may not apply broadly. The combination of multiple drugs and radiation may cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
Boston, Massachusetts, 02214, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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