Targeted drug shows promise as Post-Transplant maintenance for rare blood cancers

NCT ID NCT03515512

First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 28 times

Summary

This study tested the drug enasidenib as a maintenance therapy for people with IDH2-mutant acute myeloid leukemia or chronic myelomonocytic leukemia after a stem cell transplant. The goal was to find the safest dose and see how well patients tolerated it. Twenty-three participants were enrolled, and researchers monitored side effects and dose-limiting toxicities. The study was completed and provides early safety data for this approach.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Johns Hopkins Cancer Center

    Baltimore, Maryland, 21287, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02214, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

Conditions

Explore the condition pages connected to this study.