Does IV tylenol beat pills for Post-Surgery pain?
NCT ID NCT02216682
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving acetaminophen (Tylenol) through an IV works better than taking it as a pill for pain after knee replacement surgery. Researchers measured pain scores and how much extra opioid painkiller patients needed. The goal is to find the best way to manage pain and reduce opioid use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acetaminophen
What this could lead to
If IV acetaminophen works better, it could reduce the need for stronger painkillers like opioids after surgery.
What could go wrong
This is a small, completed study comparing two forms of a common drug. The difference may be small or not meaningful for all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States