Precision proton beam aims to zap liver tumors with fewer side effects

NCT ID NCT00976898

Completed Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested proton beam radiation, a highly targeted form of radiotherapy, in 83 people with liver cancer that could not be surgically removed. The goal was to see if this precise approach could control tumors while reducing damage to healthy tissue. Participants received daily treatments for three weeks, and researchers tracked tumor control and survival over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton beam radiation
What this could lead to: If successful, this could offer a more precise and safer radiation option for people with liver cancer that cannot be removed by surgery.
What could go wrong: This is a small, early-phase study with no comparison group. Results may not apply to all liver cancer patients, and some may still experience side effects or tumor regrowth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intrahepatic cholangiocarcinoma liver cancer Liver Neoplasms pediatric hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER CANCER

Contacts and locations

Locations

Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
University of Pennsylvania, Roberts Proton Facility

Philadelphia, Pennsylvania, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

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