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Scientists investigate hidden 'Avalanche' pattern in ARDS lungs

NCT ID NCT05224323

Knowledge-focused Sponsor: Poitiers University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how small airways open during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). Researchers want to see if an 'avalanche-like' pattern occurs, which could worsen lung injury. 50 adults with moderate-to-severe ARDS will be monitored using special pressure and imaging techniques. The goal is to better understand lung damage and improve ventilator care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors adjust ventilator settings to reduce lung damage in ARDS patients.
What could go wrong
This is a small observational study (50 participants) that only measures a phenomenon, not a treatment. It may not lead to any immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2022

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with moderate-to-severe acute respiratory distress syndrome will be included within the first 72 hours after meeting the Berlin definition criteria. After ruling out exclusion criteria and obtaining informed consent from their relatives, patients will be included in the study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 * Moderate-to-severe acute respiratory distress syndrome within the first 72 hours after meeting the Berlin definition criteria: * Within 1 week of a known clinical insult or new or worsening respiratory symptoms; * Bilateral opacities (not fully explained by effusions, lobar/lung collapse, or nodules); * Respiratory failure not fully explained by cardiac failure or fluid overload; * PaO2/FiO2 ≤ 200 mmHg with positive end-expiratory pressure ≥ 5 cmH2O. * Absence of spontaneous breathing efforts * Consent to participate to the study from the patient and/or its surrogate Exclusion Criteria: * Pneumothorax * Broncho-pleural fistula * Tracheostomy * Hemodynamic instability * Severe hypoxemia * Suspected of proven intracranial hypertension * Chronic obstructive lung disease * Pacemaker or defibrillator * Decision to withhold of withdraw life-sustaining measures * Under protection

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • CHU Poitiers

    RECRUITING

    Poitiers, 86000, France

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