ACUTE RESPIRATORY DISTRESS SYNDROME

This Phase 3 trial tests whether a treatment called ExoFlo, made from stem cell particles, can help hospitalized adults with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), a serious lung condition. About 970 participants will receive either ExoFlo or a placebo thr…

This study tests whether adding a new drug (recombinant human plasma gelsolin) to standard care can help people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive either the drug o…

This study tests whether adding umbilical cord stem cells to standard care can help people with severe lung injury (ARDS) caused by pneumonia-related sepsis recover faster and lower their risk of death. About 15 adults aged 40 and older will receive either standard treatment, ste…

This study tests a drug called bevacizumab in hospitalized adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and safety. The main goal is to measure how …

This study tests whether a special breathing machine (high-frequency oscillation) works better than standard machines for very premature babies with lung injury. About 400 babies born between 24 and 31 weeks will be randomly assigned to one of the two machines. The goal is to see…

This study tests whether giving severe ARDS patients on ECMO a near-apneic (almost no breathing) ventilation approach can reduce lung damage compared to standard care. About 280 adults will be randomly assigned to either early apneic ventilation or usual ultra-protective ventilat…

This study tests whether keeping patients with severe lung failure (ARDS) lying on their stomach for more than 48 hours straight helps them survive better than the usual 16-24 hour daily sessions. About 780 adults on breathing machines will be randomly assigned to one of the two …

This study tests a drug called vilobelimab in adults hospitalized with severe lung failure (ARDS). About 200 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces deaths within 28 days.

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The goal is to see if adding this device to standard care helps improve blood gas levels and reduce lung injury. About 99 adults with …

This study tests an experimental drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily through an IV and compared to a placebo, alongside standard care. The goal is to see if AV-001 is safe and helps patients recover faster fr…

This study tests an experimental drug called paridiprubart in adults hospitalized with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and safe…

This study is testing a new treatment for people with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. The treatment uses stem cells from human umbilical cords, given as an injection. The main goal is to see if it is safe and tolerable, and…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or one of the active drugs to see if they improve survival and recovery. The goa…

This study looks at whether keeping patients with severe lung failure (ARDS) on their stomach for 40 hours at a time, instead of the usual 16 hours, can lower the chance of death. About 800 adults on breathing machines will be randomly assigned to one of the two positions. The go…

This study tests whether sitting ARDS patients upright in bed helps them breathe better compared to standard head-of-bed elevation. Researchers will measure changes in lung function. The study involves 40 adults with ARDS who would normally be placed on their stomach (proning).

This study looks at whether safely sitting up patients with severe lung injury (ARDS) is possible and helpful. Researchers will compare sitting upright to the usual face-down position in 32 adults. The goal is to see if upright positioning is safe and can improve oxygen levels.

This study looks at how certain white blood cells (macrophages) in the lungs react to inflammation in people with Acute Respiratory Distress Syndrome (ARDS). Researchers want to understand how these cells help turn off inflammation and repair lung damage. Participants are adults …

This study looks at 170 adults in intensive care with Acute Respiratory Distress Syndrome (ARDS), a severe lung condition. Researchers want to see if a blood test measuring a clotting factor (EV-TF) can predict who will develop a pulmonary embolism (a blood clot in the lung). Par…

This study looks at 500 adults with a severe lung condition called ARDS to see if they can be grouped into two types based on their body's inflammation levels. The goal is to find out if knowing a patient's subtype can help doctors choose the best treatments, like fluids, breathi…

This study watches 100 adults who needed a machine called ECMO for severe heart or lung failure. Researchers want to see how muscle loss and weakness affect their recovery and quality of life. They will use ultrasound, strength tests, and questionnaires to track changes over time…

This study involves 20 adults with severe lung failure (ARDS) who are on a breathing machine. Researchers will use a non-invasive imaging method called electrical impedance tomography (EIT) to see how the lungs respond to different ventilator pressure settings, both when lying on…

This study looks at a phenomenon called 'avalanche' in the lungs of people with acute respiratory distress syndrome (ARDS). Researchers want to see how small airways open unevenly during mechanical breathing support. By understanding this, they hope to find ways to reduce lung da…

This study follows 550 children who needed a machine called ECMO to breathe after a sudden lung failure. Researchers want to learn how these children recover over the next year, including their thinking, movement, and quality of life. They will also compare two different ways of …

This study looks at 30 adults recovering from acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see if increasing the pressure in the lungs (called PEEP) can reduce the effort needed to breathe, which may prevent further lung damage. T…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study looks at how the heart and lungs affect each other in adults with acute respiratory distress syndrome (ARDS), a severe lung injury often caused by infections. Researchers will track 500 intensive care patients on ventilators using heart ultrasounds and medication recor…

This study observes 1,000 adults in intensive care with moderate-to-severe acute respiratory distress syndrome (ARDS) to learn how prone positioning (lying face down) affects survival and recovery. Researchers will explore whether lung shape on CT scans can guide treatment, and w…

This study looks at how the time it takes for a patient to exhale affects lung function in adults with acute respiratory distress syndrome (ARDS) who are on a ventilator. Researchers will use a special imaging technique called EIT to measure how air and blood flow are distributed…