ACUTE RESPIRATORY DISTRESS SYNDROME

This large Phase 3 trial is testing whether tiny particles released from bone marrow stem cells (called ExoFlo) can help hospitalized patients with severe Acute Respiratory Distress Syndrome (ARDS). The study will compare the treatment against a placebo in 970 patients to see if …

This study is testing a new drug called AV-001 for adults hospitalized with pneumonia from COVID-19 or other infections. The goal is to see if the drug is safe and if it can help patients improve by reducing lung inflammation and damage, potentially helping them breathe better an…

This study is testing whether a new drug called vilobelimab can help adults hospitalized with a severe lung condition called Acute Respiratory Distress Syndrome (ARDS). About 200 participants will be randomly assigned to receive either the new drug or a placebo, while all continu…

This study is testing whether adding the drug bevacizumab to standard hospital care helps adults with severe lung failure (ARDS). About 200 hospitalized patients will be randomly assigned to receive either the drug or a placebo, without doctors or patients knowing which one. The …

This study is testing if adding stem cells or their secretions to standard care can help patients with severe lung failure caused by pneumonia. It will involve 15 adults with this critical condition. Researchers will compare three groups to see if the new treatments improve lung …

This study aims to find the best breathing machine method for very premature babies who develop severe lung distress shortly after birth. It will compare two types of machines (high-frequency vs. conventional) in 400 babies born between 24 and 32 weeks. The main goal is to see wh…

This study is testing whether adding an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) to standard hospital care can help patients with severe Acute Respiratory Distress Syndrome (ARDS) caused by infections like pneumonia. ARDS is a life-threatening conditi…

This study is testing three different new drugs to see if they can help adults hospitalized with Acute Respiratory Distress Syndrome (ARDS), a severe and often deadly form of lung failure. About 600 participants will receive either one of the new treatments or a placebo, in addit…

This study is testing if keeping patients with severe lung failure (ARDS) in an upright position in bed helps them breathe better while on a ventilator. It will compare this upright positioning to the standard practice of just raising the head of the bed. The goal is to see if th…

This early-stage study is testing the safety of an experimental injection made from umbilical cord stem cells for people with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. The main goal is to see if the treatment is safe and to …

This study is testing if keeping patients with severe Acute Respiratory Distress Syndrome (ARDS) lying on their stomachs for longer periods (40 hours) saves more lives than the standard shorter sessions (16 hours). It will involve 800 critically ill patients who are on breathing …

This study aims to find the best way to position patients with severe lung failure (ARDS) to help them survive. It will compare keeping patients on their stomachs for more than 48 hours at a time versus turning them on their stomachs for 16-24 hours each day. Researchers will tra…

This study is testing whether a new drug called paridiprubart can help hospitalized adults with Acute Respiratory Distress Syndrome (ARDS), a severe and life-threatening form of lung failure. About 200 participants will be randomly assigned to receive either the new drug or a pla…

This study is testing a medical device called PrismaLung+ that helps remove excess carbon dioxide from the blood of critically ill patients who are on breathing machines. The research will compare patients using the device along with standard ventilator care against those using o…

This study is testing whether carefully raising patients with severe lung failure (ARDS) to a more upright position in bed is safe and practical. It will compare this 'verticalization' technique to the standard 'prone' (face-down) position to see if it helps patients get similar …

This study aims to better understand how and when to safely place patients with severe lung failure (ARDS) in a face-down position to help them breathe. Researchers will observe 1,000 critically ill adults in intensive care units to see if this positioning works better for certai…

This study aims to understand how tiny airways open in patients with severe lung failure (ARDS) who are on breathing machines. Researchers will measure pressure changes in the lungs of 50 patients to see if airways open in a chain reaction, like an 'avalanche.' The goal is to gat…

This study aims to understand how a specific setting on a breathing machine affects how air and blood flow are distributed in the lungs of patients with Acute Respiratory Distress Syndrome (ARDS). Researchers will enroll 60 adult patients who are on a ventilator for ARDS. They wi…

This study aims to learn if a special imaging technique can help doctors better adjust ventilator settings for patients with severe lung failure (ARDS). Researchers will use the imaging to see how different air pressure levels affect the lungs when patients are lying on their bac…

This study aims to better understand how the heart is affected in patients with severe lung failure (ARDS) who are on breathing machines. Researchers will observe 500 critically ill adults to see how often and in what ways heart strain develops during treatment. The goal is to ga…

This study aims to understand how white blood cells called macrophages respond to severe lung inflammation in patients with Acute Respiratory Distress Syndrome (ARDS). Researchers will collect lung fluid, blood, and nasal samples from 56 critically ill patients on breathing machi…

This study aims to understand why some patients develop severe muscle weakness after surviving a life-threatening heart or lung failure that required advanced life support (ECMO) in the intensive care unit. Researchers will observe 100 adult patients to see how their muscle size,…

This study aims to understand the long-term recovery of children who receive ECMO, a form of life support for severe breathing failure. It will compare outcomes between children who receive ECMO as usual care and those managed with a strict ventilator protocol that uses ECMO only…

This study aims to understand if grouping patients with Acute Respiratory Distress Syndrome (ARDS) by their level of inflammation can help doctors choose better treatments. Researchers will follow 500 adults in China with severe ARDS to see if using a model to classify them as 'h…

This study is creating a large international registry to collect real-world data on how a medical device called CytoSorb is used in critical care. The device filters harmful substances from a patient's blood and is used for various severe conditions like septic shock, severe trau…

This study is testing if a drug called Racecadotril, which is normally used for diarrhea, can reduce fluid leaks in a safe skin blister model. Researchers are using this model to see if the drug might help strengthen blood vessel barriers, which could be important for treating a …

This study aims to find out if a specific substance in the blood (called EV-TF) can help predict which patients with severe lung failure (ARDS) will develop a dangerous lung clot (pulmonary embolism). Researchers will enroll 170 critically ill patients in France, take a blood sam…