Chilling the body to save the lungs: new trial for ARDS
NCT ID NCT04545424
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether gently cooling the body (to 34-35°C) combined with muscle-paralyzing drugs can help people with severe lung injury (ARDS) recover. About 340 adults on ventilators will be randomly assigned to cooling plus paralytics or usual care. The main goal is to see if cooling increases the number of days alive and off a ventilator within 28 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- therapeutic hypothermia (cooling blankets or gel-pads) and neuromuscular blocking agents (paralytics)
- What this could lead to
- If it works, this could point toward a new treatment that helps ARDS patients recover faster and spend less time on a ventilator.
- What could go wrong
- This is an early Phase 2 trial, so results may not be conclusive. Cooling can cause shivering, which requires deep sedation and paralysis, and the added risks of those drugs must be weighed.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Brooke Army Medical Center
TERMINATEDFort Sam Houston, Texas, 78234, United States
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Cedars-Sinai Medical Center
NOT_YET_RECRUITINGLos Angeles, California, 90048, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinc
RECRUITINGCleveland, Ohio, 44195, United States
Contact Email: •••••@•••••
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Cooper Health System
RECRUITINGCamden, New Jersey, 08103, United States
Contact Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Email: •••••@•••••
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Intermountain Healthcare (Utah)
RECRUITINGSalt Lake City, Utah, 84132, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins Hospital
TERMINATEDBaltimore, Maryland, 21205, United States
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Loyola University Chicago
TERMINATEDChicago, Illinois, 60660, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
Contact Email: •••••@•••••
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Thomas Jefferson University
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Email: •••••@•••••
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45219, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky
NOT_YET_RECRUITINGLexington, Kentucky, 40536, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland Medical Center
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylavia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Contact Email: •••••@•••••
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University of Wisconsin
TERMINATEDMadison, Wisconsin, 53792, United States
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Yale University
TERMINATEDNew Haven, Connecticut, 06520, United States
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