Could 'lung rest' on ECMO save more lives in severe ARDS?

NCT ID NCT06814340

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether giving the lungs a near-complete rest (apneic ventilation) early after starting ECMO helps people with the most severe form of acute respiratory distress syndrome (ARDS). About 280 participants will be randomly assigned to either near-apneic ventilation or standard ultra-protective lung ventilation. The goal is to see if this approach reduces lung injury, shortens time on ECMO, and improves survival at 60 days.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY DISTRESS SYNDROME EXTRACORPOREAL MEMBRANE OXYGENATION COMPLICATION

Contacts and locations

Locations

Avicenne Hospital
RECRUITING

Bobigny, France
Brabois Hospital - CHRU Nancy
RECRUITING

Nancy, France
CHU Orléans
RECRUITING

Orléans, France
CHU Tours
RECRUITING

Tours, France
Croix-Rousse Hospital - HCL
RECRUITING

Lyon, France
Haut Levèque Hospital - CHU Bordeaux
RECRUITING

Bordeaux, France
Henri Mondor Hospital
RECRUITING

Créteil, France
Mercy Hospital - CHR Metz
RECRUITING

Metz, France
North Hospital - APHM
RECRUITING

Marseille, France
Pitié-Salpêtrière Hospital
RECRUITING

Paris, France
Pontchaillou Hospital - CHU Rennes
RECRUITING

Rennes, France

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