ACUTE RESPIRATORY DISTRESS SYNDROME

This study tested whether using a special antiseptic dressing on the tubes that connect patients to an ECMO machine (a heart-lung bypass for critically ill people) can reduce serious infections. About 270 adults on ECMO for heart or lung failure were randomly assigned to get eith…

This study tested whether a single dose of donor stem cells given through an IV could help COVID-19 patients with severe lung failure breathe better. Twenty adults took part, and the main goal was to see if oxygen levels in the blood improved within a week. The treatment aims to …

This study looked at whether a sedation drug called sevoflurane, given as a gas to breathe, could help people with severe lung injury (ARDS) live longer and need a breathing machine for fewer days. About 700 adults were randomly assigned to receive either sevoflurane or the stand…

This small pilot study tested a non-invasive device that stimulates the vagus nerve (a key nerve connecting the brain and body) in people hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if this stimulation, added to standard care, could prevent seve…

This study tested a new way of using breathing machines in 220 adults with severe COVID-19 lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. Participants were randoml…

This study looked at whether giving a gas called sevoflurane (used for sleep during surgery) for 48 hours can improve oxygen levels and reduce inflammation in people with acute respiratory distress syndrome (ARDS), a severe lung condition. Fifty adults with moderate to severe ARD…

This study tested if placing patients with severe acute respiratory distress syndrome (ARDS) on their stomachs (prone position) for at least 16 hours a day could lower the chance of dying. 474 adults on breathing machines were randomly assigned to either prone or standard (face-u…

This study tested a drug called sivelestat sodium in 324 adults with acute respiratory distress syndrome (ARDS) and systemic inflammation. The goal was to see if the drug could improve oxygen levels and reduce the need for a breathing machine. The drug works by blocking a harmful…

This study tested a new way to use a breathing machine to protect the heart in patients with severe lung injury (ARDS). The method uses pressure measurements inside the lungs to guide ventilation. 40 adults on breathing machines for less than 72 hours took part. The goal was to s…

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not able to use a breathing machine. About 600 adults took part. The goal was to see if this simple position change could lower the chance of d…

This study tested whether having COVID-19 patients with serious breathing problems lie face down (prone position) while receiving high-flow oxygen could reduce the need for breathing tubes and intensive care. Researchers enrolled 405 adults with COVID-19 pneumonia and acute respi…

This study looked at 25 adults in the ICU with moderate to severe acute respiratory distress syndrome (ARDS). The goal was to test a new, simple way to measure if airflow is blocked when they breathe out. Researchers compared results in different body positions and at different b…

This study followed over 4,000 patients in Chinese ICUs who needed breathing support for acute respiratory failure. Researchers collected data on treatments, outcomes, and costs to better understand the disease burden. The goal is to improve care and inform future guidelines.

This study looked at whether gently pressing on the front of the chest can improve how air and blood move in the lungs of people with severe lung injury (ARDS). 20 adults on breathing machines took part. Researchers used special imaging to measure lung function and heart performa…

This study examined 30 ICU patients on ventilators for severe H1N1 flu. Researchers analyzed lung fluid and blood to understand how the virus and the body's immune response interact. The goal was to find better ways to treat severe flu and prevent lung damage.

This study looked at 11 adults with acute respiratory distress syndrome (ARDS) to see if their body position (lying flat at 0° or slightly raised at 30°) changes the accuracy of esophageal pressure measurements used to set ventilators. Researchers measured pressure at both angles…

This study looked at 50 adults and children with acute respiratory distress syndrome (ARDS) who were on breathing machines. The goal was to see if the pressure in the lungs affects the right side of the heart. Researchers measured lung pressure and used ultrasound to check heart …

This study followed 38 children who survived acute respiratory distress syndrome (ARDS) to see how their lungs were doing one year later. Researchers measured lung stiffness, breathing symptoms like cough and wheeze, and looked at CT scans for any lasting damage. The goal was to …

This study looked at 60 adults with severe lung injury (ARDS) on breathing machines. It compared two ventilation methods—APRV and low tidal volume—to see which one better protects the right side of the heart from strain. The goal was to find out if one method reduces heart compli…

This study looked at stored blood samples from about 300 adults hospitalized with COVID-19 to see if a protein called suPAR could predict who would develop severe breathing failure needing a ventilator. Researchers measured suPAR levels and checked medical records for outcomes. T…

This study enrolled 513 children on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers collected blood samples to identify different biological types of the disease, aiming to better predict outcomes and tailor future therapies. No new treatment was…

This study tested a program called R2 to improve the care, environment, and sleep patterns of children in the pediatric intensive care unit (PICU). Researchers observed 56 children to see how changes in light, sound, and daily routines affected their healing and natural sleep-wak…

This study tested whether a small ultrasound probe placed in the throat could help predict how long people with severe lung failure (ARDS) need a breathing machine. Researchers measured a heart-related sign that might show fluid overload or heart strain. 50 adults in intensive ca…

This study looked at 32 adults with severe lung failure (ARDS) who were on breathing machines. Researchers measured pressure inside the lungs when patients were lying on their back versus on their stomach (prone position). The goal was to see if stomach-lying changes lung pressur…

This study looked at 94 adults with acute respiratory distress syndrome (ARDS) who needed a breathing tube and were placed on their stomachs (prone position) to help them breathe. Researchers used a special, non-invasive imaging tool called electrical impedance tomography (EIT) t…

This study looked at how COVID-19 causes organ failure in intensive care patients. Researchers tracked 380 adults with suspected or confirmed COVID-19 in the ICU, measuring kidney injury, breathing problems, and survival rates. The goal was to better understand the disease, not t…