Can a common anesthetic help ARDS patients breathe easier?
NCT ID NCT04235608
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether using sevoflurane (an inhaled anesthetic) for sedation could lower death rates and shorten time on a ventilator in patients with acute respiratory distress syndrome (ARDS). 700 adults were randomly assigned to receive either sevoflurane or standard propofol sedation. The goal was to see if sevoflurane improves outcomes like days alive and off the ventilator.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sevoflurane (inhaled anesthetic)
- What this could lead to
- If it works, this could offer a better sedation method for ARDS patients, potentially reducing time on a ventilator and improving survival.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet widely known. The benefit may be small or not apply to all ARDS patients. Inhaled sedation also requires special equipment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Carémeaux Hospital - University Hospita
Nîmes, France
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Cavale Blanche Hospital - University Hospital
Brest, France
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Diaconesses - La Croix Simon Hospital
Paris, France
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Hautepierre Hospital, University Hospitals
Strasbourg, France
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Hospital
Béthune, France
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Hospital
Cannes, France
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Hospital
Dunkirk, France
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Hospital
Melun, 77000, France
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Hospital
Saint-Brieuc, France
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Hospital
Saintes, France
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Hospital Belfort
Belfort, France
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Hospital Chartres
Chartres, France
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Hospital Martigues
Martigues, France
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Hospital Saint-Nazaire
Saint-Nazaire, France
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Hospital Valenciennes
Valenciennes, France
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Hotel Dieu Hospital - University Hospital
Nantes, France
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Jean Perrin Comprehensive Cancer Center
Clermont-Ferrand, France
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Lapeyronie Hospital - University Hospital
Montpellier, France
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Pasteur 2 Hospital - University Hospital
Nice, France
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Pitié-Salpêtrière Hospital, - Assistance Publique-Hôpitaux
Paris, France
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Saint-Antoine University Hospital - Assistance Publique-Hôpitaux
Paris, France
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Saint-Eloi Hospital - University Hospital
Montpellier, France
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Saint-Louis University Hospital - Assistance Publique-Hôpitaux
Paris, France
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Salengro Hospital - University Hospital
Lille, France
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Timone Hospital - Assistance Publique-Hôpitaux
Marseille, France
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University Hospital
Amiens, France
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University Hospital
Angers, France
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University Hospital
Clermont-Ferrand, France
-
University Hospital
Dijon, France
-
University Hospital
Poitiers, France
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University Hospital
Reims, France
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University Hospital
Rennes, France
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University Hospital,
Clermont-Ferrand, 63011, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Lung-Opening maneuver change a key injury marker in ARDS?
- Could simply sitting up ease breathing in severe lung failure?
- Could lung fluid proteins reveal a new way to track severe lung injury?
- Could a spirometer test guide breathing support in respiratory failure?
- Which ventilator setting saves more lungs? a Head-to-Head test
- Can a single antibody turn down the immune storm in ARDS?