Experimental drug aims to help ARDS patients breathe easier
NCT ID NCT05496868
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tested whether adding reparixin, an anti-inflammatory drug, to standard care could improve lung function in adults with moderate to severe acute respiratory distress syndrome (ARDS). The study enrolled 66 patients on mechanical ventilators. Researchers measured changes in oxygenation and how many days patients were free from the ventilator. The goal was to see if reparixin could speed recovery and reduce inflammation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Reparixin (an experimental anti-inflammatory drug)
What this could lead to
If successful, reparixin could help reduce lung injury and shorten the time patients with ARDS need a ventilator, potentially improving recovery.
What could go wrong
This is an early Phase 2 trial with only 66 participants, so results may not apply to all ARDS patients. The drug may not show clear benefit over standard care, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner - University Medical Center Phoenix
Phoenix, Arizona, 85006, United States
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Baptist Hospitals of Southeast Texas
Beaumont, Texas, 77701, United States
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Baystate Health
Springfield, Massachusetts, 01107, United States
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Berufsgenossenschaftliche Kliniken Bergmannstrost
Halle, Saxony-Anhalt, 6112, Germany
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Cardiovoyage
Denison, Texas, 75020, United States
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Denver Health
Denver, Colorado, 80204, United States
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Detroit Medical Center
Detroit, Michigan, 48201, United States
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342, United States
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Hackensack Meridian Health
Hackensack, New Jersey, 07601, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Herzzentrum Muenster
Münster, North Rhine-Westphalia, 48149, Germany
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Jackson Pulmonary Associates
Jackson, Mississippi, 39202, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Methodist Hospitals of Northwest Indiana
Gary, Indiana, 46404, United States
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MyMichigan Medical Center Midland
Midland, Michigan, 48670, United States
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NYU Langone Brooklyn
Brooklyn, New York, 11220, United States
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New York University Langone Health
New York, New York, 10016, United States
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Newton Wellesley Hospital
Newton, Massachusetts, 02462-1607, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Ospedale San Raffaele
Milan, Lombardy, 20132, Italy
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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The University of Alabama at Birmingham Hospital
Birmingham, Alabama, 35233, United States
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Universitaetsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Universitaetsklinikum Leipzig
Leipzig, Saxony, 4103, Germany
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Universitaetsmedizin Goettingen
Göttingen, Lower Saxony, 37075, Germany
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University Hospital of Schleswig-Holstein
Kiel, Schleswig-Holstein, 24105, Germany
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University of California Irvine Health
Orange, California, 92868, United States
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University of Missouri Health Care
Columbia, Missouri, 65212, United States
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University of Oklahoma Medical Center
Oklahoma City, Oklahoma, 73104, United States
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University of South Florida
Tampa, Florida, 33606, United States
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University of Southern California
Los Angeles, California, 90033, United States
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University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390-8894, United States
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University of Utah Hospitals & Clinics
Salt Lake City, Utah, 84108, United States
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Unversity of California Davis Medical Center
Sacramento, California, 95817, United States
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Virginia Commonwealth University Health System
Richmond, Virginia, 23298, United States
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William Beaumont Hospital
Royal Oak, Michigan, 48073, United States