ACUTE RESPIRATORY DISTRESS SYNDROME

This study aimed to test a drug called IC14 in people with acute respiratory distress syndrome (ARDS), a severe lung condition. Participants would have received either IC14 or a placebo for 4 days and been followed for 28 days. The trial was withdrawn before enrolling anyone, so …

This study looks at whether a step-by-step care plan, called TheraPPP, helps doctors better treat patients with severe breathing failure (ARDS). The plan includes using protective ventilation, paralysis, and prone positioning. About 20,000 adults on breathing machines in Alberta …

This study aimed to see if adding two immune therapies—a drug called nogapendekin alfa inbakicept and special immune cells (iNKT cells)—to standard care could help critically ill adults with severe pneumonia, sepsis, or lung failure recover. It was designed for adults in the ICU …

This study tests whether a single infusion of mesenchymal stem cells (MSCs) can help treat acute respiratory distress syndrome (ARDS), a severe lung condition common in ICU patients, including those with COVID-19. About 129 adults on ventilators will first receive different doses…

This study aimed to test the safety and effects of an experimental stem cell treatment (BX-U001) for adults hospitalized with severe COVID-19 pneumonia and serious breathing problems (ARDS). The trial was designed in two parts: first to find a safe dose, and then to compare that …

This early-phase study tests whether low doses of inhaled carbon monoxide can be safely given to adults with severe lung injury caused by sepsis or pneumonia. The main goal is to check safety and see if a personalized dosing formula works. Only 5 participants are enrolled, so res…

This study looks at how often severe COVID-19 leads to lung scarring (pulmonary fibrosis) and what factors increase that risk. Researchers will follow 200 intensive care patients to see if scarring affects survival and recovery. The goal is to better understand and predict this c…

This study looks at whether a drug called Racecadotril can reduce fluid leakage in skin blisters. The blisters are a safe model for what happens in the lungs of patients with Acute Respiratory Distress Syndrome (ARDS), a severe lung injury with no effective treatments. Healthy vo…

This study looks at whether a heart MRI can be done safely in children with cancer who have recently had sepsis, a serious infection. The goal is to find hidden heart problems early so doctors can adjust treatments. About 7 participants aged 9 to 25 will be scanned within 10 days…

This study observes how medical teams handle patients exposed to chemical, biological, radiological, nuclear, or explosive attacks. Researchers will track whether World Health Organization guidelines are followed without delay during rescue and treatment. About 1,000 patients fro…