New drug shows promise for ARDS patients in major trial
NCT ID NCT04909697
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This clinical trial tested a drug called sivelestat sodium in 324 adults with acute respiratory distress syndrome (ARDS) and systemic inflammation. The drug aims to block a harmful enzyme that damages lung tissue. Researchers measured whether it improved oxygen levels and reduced the need for a breathing machine.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sivelestat sodium
What this could lead to
If it works, this could provide a new treatment option for ARDS patients, potentially improving oxygen levels and reducing time on a ventilator.
What could go wrong
This is a completed Phase 4 trial, but results are not yet widely reported. The drug may not show significant benefit over standard care, and side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sichuan provincial people's hospital
Chengdu, Sichuan Privince, China