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Can upright positioning help ARDS patients breathe easier?

NCT ID NCT04472260

Symptom relief Sponsor: Centre Hospitalier Régional d'Orléans Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether safely raising patients with acute respiratory distress syndrome (ARDS) to an upright position (verticalization) is feasible and safe. Researchers will compare upright positioning with standard prone positioning in 32 adults. The goal is to see if upright positioning can improve oxygen levels without causing serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Verticalization (upright positioning) and prone positioning procedures
What this could lead to
If successful, this could offer a safe alternative or addition to prone positioning for ARDS patients, potentially improving oxygen levels and reducing complications.
What could go wrong
This is a small, early feasibility study with only 32 participants, so results may not apply broadly. The procedure may not improve outcomes or could cause adverse events like pressure ulcers or tube issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2021

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Major patient \> 18 years of age * ARDS patients with PaO2/FiO2 ratio \< 150 at any time within 24 hours prior to the screening visit * Hemodynamically stable patient with mean arterial pressure (MAP) \> 65 mmHg maintained without vasopressor or with norepinephrine at a dosage of less than 0.5 µg/kg/min. * Patient having already undergone at least 1 but less than 5 PP sessions * Patient under continuous intravenous sedation (IVSE) or not responding to simple order. * Written consent of support person or family. Exclusion Criteria: * Pregnant women (positive pregnancy test during screening) * Breastfeeding women * Protected Majors * Body weight greater than 198 kg (bed load limit) * Patient with one or two lower limbs amputated at the trans tibial or upper level * Contraindication to standing (orthopedic fracture, neurological instability with the presence of an intracranial pressure sensor or an external ventricular shunt....) * Deep venous thrombosis of the lower limbs with curative anticoagulation for less than 48 hours * Hemodynamic instability (MAP \< 65 mm Hg) despite the use of norepinephrine at a dosage equal or greater than 0.5 µg/kg/min. * Person under guardianship or trusteeship * Non-beneficiary patient of a health insurance plan * Moribund patient

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome Prone position

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • CHR d'ORLEANS

    RECRUITING

    Orléans, France

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