Centre Hospitalier Régional D'orléans

This study is testing two different ways to remove a breathing tube from patients in the intensive care unit (ICU). Researchers want to know if using suction to clear the tube right before removal helps patients breathe better afterwards compared to not using suction. About 120 a…

This study is testing whether carefully raising patients with severe lung failure (ARDS) to a more upright position in bed is safe and practical. It will compare this 'verticalization' technique to the standard 'prone' (face-down) position to see if it helps patients get similar …

This study is testing if blood drawn from a patient's existing central line (a tube in a large vein) gives the same accurate result for a common blood-thinner test as the standard, often painful, needle stick in the arm. Researchers will compare two different flushing methods for…

This study aims to see if measuring calf circumference with a simple tape measure is as good as a specialized X-ray scan for diagnosing sarcopenia (serious muscle loss) in hospitalized people aged 75 and older. Researchers will compare the two methods in 298 participants to check…

This study is testing whether getting ICU patients who are on breathing machines to sit in a chair helps them recover their strength and ability to move. Researchers will compare patients who sit in a chair to those who stay sitting up in bed. The goal is to see if this simple ch…

This study aims to find the best way to reduce pain from monthly injections of HIV medication. It will test if using a virtual reality headset as a distraction or injecting in a different spot on the buttock helps. About 120 adults with well-controlled HIV will try all four combi…

This study is testing whether a special training program using your own voice, hearing, and body movements can help reduce the distress caused by chronic tinnitus (ringing in the ears). Researchers are enrolling 56 adults with bothersome tinnitus to see if this training improves …

This small, early study is testing whether using a robotic arm to hold an ultrasound device helps doctors give steroid injections for carpal tunnel syndrome. It will compare the robot-assisted method to the standard manual method in 20 patients to see if it's safe, accurate, and …

This study is testing whether daily breathing muscle training can help reduce daytime sleepiness in adults with obstructive sleep apnea. Researchers will compare a group doing the breathing exercises with a group receiving standard care. The goal is to see if this simple training…

This study aims to understand how taking probiotics and/or doing regular exercise affects body composition, fitness, stress, and gut health in healthy women. 120 non-athletic female students will be randomly assigned to take either probiotics or a placebo, and to either exercise …

This study aims to understand how HIV affects the body's cellular cleanup system called autophagy, even in patients whose virus is well-controlled with medication. Researchers will compare blood samples from 180 HIV-positive adults on different treatment paths with samples from h…

This study aims to understand how long protective antibodies last in people's blood and noses after they receive vaccines or antibody treatments for COVID-19 or Monkeypox. Researchers will follow 30 adults for up to 5 years, collecting samples to measure antibody levels over time…

This is a long-term observational study aiming to understand why medical students experience high rates of depression and anxiety. Researchers will follow up to 10,000 students over many years, comparing those in medical school to those who were not accepted. The goal is to ident…

This study aims to find out if simple body measurements can help predict how well someone will recover after a stroke. Researchers will measure muscle mass and composition in 250 stroke patients shortly after their stroke. They will then check if these measurements are linked to …

This study aims to understand if and how much CBD passes from mothers into breast milk and their babies. Researchers will recruit 60 breastfeeding mothers in France who use CBD and measure CBD levels in their blood, milk, and their infants' urine. The goal is to gather basic safe…

This study aims to find out if a simple facemask can reliably measure oxygen levels in critically ill patients who need an emergency breathing tube. Currently, doctors use a more invasive method. Researchers will compare oxygen readings from a standard facemask to readings from a…

This study aims to see if food allergy skin tests give the same results when using fresh food versus food that has been frozen or stored for a while. Researchers will test 100 adults with diagnosed food allergies by performing skin prick tests with both fresh and stored samples o…

This study aims to understand how chronic kidney disease affects the immune system, particularly why patients with advanced disease are more vulnerable to serious infections. Researchers will compare blood samples from 100 people across three groups: those with end-stage kidney d…

This study aims to understand how different compounds from the cannabis plant affect immune cells in a lab setting. Researchers will collect blood from 100 patients with chronic inflammatory diseases like rheumatoid arthritis and lupus. They will test various cannabis extracts on…