Centre Hospitalier Régional D'orléans

This study tests whether measuring calf circumference with a tape measure can accurately diagnose sarcopenia (muscle loss) in hospitalized adults aged 75 and older. Researchers will compare the tape measure results to a standard X-ray method. If successful, this could offer a sim…

This study looks at whether moving patients on breathing machines out of bed and into a chair helps them regain strength and function faster. About 150 adults in the ICU will be randomly assigned to either sit in a chair or stay sitting up in bed. The goal is to see if chair posi…

This study tests two simple ways to reduce pain from HIV injections: changing the injection site (hip vs. buttock) and using a virtual reality headset during the shot. About 120 people with HIV will try all four combinations and rate their pain for a week. The goal is to find the…

This study tests whether a new device that uses cold helium plasma is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold …

This study tests a training program that uses your own voice to mask or reduce the ringing of tinnitus. 56 adults with chronic tinnitus will either receive the training or not, and researchers will measure changes in symptoms and brain activity using EEG. The goal is to see if th…

This study tests whether training the muscles used for breathing in (inspiratory muscle training) can reduce daytime sleepiness in adults with obstructive sleep apnea who already use a CPAP machine. About 58 participants will be randomly assigned to add breathing exercises or con…

This study tests whether a continuous apomorphine pump can reduce muscle stiffness and improve comfort for people with advanced Parkinson's disease who are nearing the end of life. About 80 participants who are already receiving home hospital care will be enrolled. The goal is to…

This study looks at whether safely sitting up patients with severe lung injury (ARDS) is possible and helpful. Researchers will compare sitting upright to the usual face-down position in 32 adults. The goal is to see if upright positioning is safe and can improve oxygen levels.

This study tests whether using a robotic arm to guide an ultrasound probe during carpal tunnel injections is better than the standard manual method. Twenty adults with moderate to severe carpal tunnel syndrome will receive a corticosteroid injection either by the robot-assisted o…

This study looks at whether using suction when removing a breathing tube helps ICU patients breathe better afterward. About 120 adults who have been on a breathing machine for over 48 hours will take part. Researchers will check oxygen levels for three hours after tube removal to…

This study looks at whether taking probiotics, doing physical activity, or both can improve body composition and health in healthy women. Researchers will compare four groups: probiotics with exercise, probiotics alone, placebo with exercise, and placebo alone. The goal is to see…

This study looks at how runners' emotions and coping strategies change during an 80-kilometer ultra-endurance race and how these factors affect their performance and fatigue. Researchers will track 80 healthy adult participants before, during, and after the race using surveys and…

This study checks if measuring oxygen in exhaled air through a facemask is reliable for critically ill patients who need a breathing tube. Low oxygen is a common complication during this procedure. Researchers will compare facemask readings to a more direct measurement in the thr…

This study looks at how HIV affects a natural cell process called autophagy, which helps clean up damaged parts of cells. Researchers will compare blood samples from 180 HIV-positive people (on therapy or untreated) and healthy volunteers. The goal is to understand why immune cel…

This study aims to make sure a foot health questionnaire, originally in English, works properly in French. Researchers will test it with 150 adults visiting a podiatry clinic in France. The goal is to confirm the survey accurately measures foot health and quality of life, so it c…

This study looks at how much CBD passes from a mother's blood into her breast milk and whether it can be found in her baby's urine. Researchers will measure CBD levels in mothers and infants over time. The goal is to understand the potential risks to breastfed children when mothe…

This study looks at 600 adults with difficult-to-treat Pseudomonas infections to see which antibiotic works best. Researchers will compare newer drugs like cefiderocol with older ones like colistin. The goal is to find the most effective treatment and improve patient outcomes.

This study is looking at how well antibodies in the blood and nose can neutralize the viruses that cause COVID-19 and monkeypox. Researchers will follow 30 adults who have received vaccines or antibody treatments to see how this protection changes over time. The goal is to better…

This study explores whether simple body measurements, like muscle size and electrical properties, can help predict how well someone will recover after a stroke. Researchers will measure the thickness and surface area of a jaw muscle and use a special scale to assess body composit…

This study looks at two different ways to give oxygen to healthy adults before anesthesia. Researchers will measure oxygen levels in the breath and blood to see which method works better. The goal is to learn more about how to prepare patients safely for medical procedures.

This study looks at how chronic kidney disease weakens the immune system, specifically T-cells, in 100 patients. Researchers will analyze blood samples to understand the immune defects. They will also test a new method in the lab to engineer T-cells using mRNA, aiming to restore …

This study looks at whether blood samples taken from a central venous catheter (a large tube in a neck, chest, or groin vein) can give accurate readings of the blood thinner heparin, compared to the usual method of drawing blood from a vein in the arm. About 30 intensive care uni…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take blood samples and expose the cells to different ca…

This study looks at how runners' minds cope during a very long 120-kilometer race. Researchers want to understand how defense mechanisms and emotional control affect feelings and tiredness. About 80 healthy adults who are already signed up for the race will take part. The goal is…

This study looks at whether using frozen or stored foods for allergy skin prick tests gives the same results as fresh foods. Researchers will test 100 adults with known food allergies using both fresh and stored samples. The goal is to see if food storage affects test accuracy, w…

This study aims to understand why medical students develop depression and other mental health problems. Researchers will follow up to 10,000 students for up to 12 years each, comparing those who enter medical school with those who do not. Participants fill out yearly online quest…