Centre Hospitalier Régional D'orléans

This study looks at 600 adults with infections caused by a hard-to-treat bacteria called Pseudomonas aeruginosa. Researchers will compare newer and older antibiotics to see which works best to cure the infection. The goal is to find the most effective treatment for these dangerou…

This study compares using a tape measure around the calf to a standard X-ray method for diagnosing sarcopenia (age-related muscle loss) in hospitalized adults aged 75 and older. Researchers will measure calf, arm, and thigh circumferences in 298 participants and see how well thes…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study tests whether a continuous apomorphine pump can reduce stiffness and improve comfort in Parkinson's patients who are near the end of life and can no longer take oral medications. Researchers will follow 80 patients receiving home hospital care, measuring symptoms like …

This study tests whether using a robotic arm to guide injections for carpal tunnel syndrome is better than the standard manual method. Twenty adults with moderate to severe carpal tunnel syndrome will receive a corticosteroid injection either by robot or by hand. The goal is to s…

This study tests whether changing the injection site (buttock vs. hip) or using a virtual reality headset can lower pain from HIV medications. 120 people with HIV will each try all four combinations and rate their pain. The goal is to find a simple way to make these injections mo…

This study tests whether safely raising patients with acute respiratory distress syndrome (ARDS) to an upright position (verticalization) is feasible and safe. Researchers will compare upright positioning with standard prone positioning in 32 adults. The goal is to see if upright…

This study tests whether a breathing exercise program can reduce daytime sleepiness in adults with obstructive sleep apnea who already use a CPAP machine. Participants will do 12-20 minute sessions of inhaling against resistance three times a week. The goal is to see if strengthe…

This study tests whether a 5-week audio-proprio-phonatory training program can reduce the daily-life disability caused by chronic tinnitus. 56 adults with tinnitus will either receive the training or not, and researchers will use brain wave recordings (EEG) and questionnaires to …

This study looks at whether moving patients on breathing machines out of bed and into a chair helps them regain strength and function better than staying in bed. About 150 adults in the ICU will be randomly assigned to either chair sitting or bed rest. The goal is to see if chair…

This study looks at how well the immune system works in people with end-stage kidney disease. Researchers will take blood samples from 100 patients and healthy donors to study T-cells, a key part of the immune system. They also plan to test a lab technique to restore T-cell funct…

This study looks at whether being left-handed or right-handed affects how well people recover arm movement after a stroke. Researchers will follow 500 adults who had a recent stroke for 6 months, measuring arm function with standard tests. The goal is to see if left-handed people…

This study looks at 24 ICU patients on breathing machines who are ready to try breathing on their own. Doctors will use heart ultrasound to see which of three breathing tests is easiest on the heart. The goal is to find the best way to help patients safely stop using the breathin…

This study is testing a French version of a questionnaire that measures foot health and its impact on daily life. Researchers will ask 150 patients with foot problems to fill out the questionnaire along with other surveys. The goal is to make sure the French version is accurate a…

This study is looking at whether simple body measurements, like muscle size and body composition, can help predict how well someone will recover after a stroke. Researchers will measure the thickness and size of a specific muscle in the head and use a special scale to check body …

This study looks at how much CBD (a legal substance found in cannabis) passes from a mother into her breast milk and whether it can be found in her baby's urine. Researchers will measure CBD levels in the blood and milk of 60 breastfeeding mothers who use CBD. The goal is to unde…

This study looks at whether measuring oxygen levels on a facemask is reliable for critically ill patients who need a breathing tube. Doctors usually rely on pulse oximetry, but that can be misleading. The researchers will compare facemask readings with a more accurate pharyngeal …

This study looks at whether frozen or stored foods can be used for allergy skin prick tests instead of fresh foods. Researchers will test 100 adults with known food allergies using both fresh and stored foods to see if the results match. The goal is to make allergy testing easier…

This study looks at how HIV affects a natural cell cleanup process called autophagy in people with HIV. Researchers will compare blood cells from 180 participants, including those on HIV medication, rare controllers, and healthy volunteers. The goal is to understand why cell clea…

This study looks at whether taking probiotics, doing physical activity, or both can change body composition and health in healthy women. 120 female university students who do not currently exercise will be split into four groups: probiotics with exercise, probiotics alone, placeb…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study looks at whether suctioning the airway before removing a breathing tube helps ICU patients breathe better afterward. About 120 adults who have been on a breathing machine for more than 48 hours will take part. Researchers will check oxygen levels for three hours after …

This study will follow 30 adults who have received vaccines or antibody treatments for COVID-19 or monkeypox. Researchers will take blood and optional nasal swabs over time to measure how well the body's antibodies neutralize these viruses. The goal is to better understand how lo…

This study looks at whether blood samples taken from a central venous catheter (a large tube in a neck, chest, or groin vein) can give reliable readings of the blood thinner heparin, compared to the standard method of drawing blood from a vein in the arm. Researchers will test tw…