Centre Hospitalier Régional D'orléans

This study tested whether high-flow nasal oxygen therapy works as well as standard noninvasive ventilation for people with a moderate COPD flare-up. Fifty-one patients were randomly assigned to one of the two treatments for the first 24 hours. The main goal was to see how each me…

This study looked at whether shiatsu, a type of bodywork using finger pressure, can reduce fatigue in people with axial spondyloarthritis (a form of arthritis affecting the spine). 72 adults with the condition were randomly assigned to receive shiatsu sessions or continue usual c…

This study tested whether letting patients move freely between the injection of a radioactive tracer and the PET scan affects image quality. Normally, patients must rest for an hour to avoid muscle uptake that can blur results. The trial involved 284 adults with cancer or needing…

This study looked at how 12 healthy adults coped emotionally during an 80-kilometer ultra-endurance race. Researchers measured defense mechanisms, emotional intensity, and fatigue before, during, and after the event. The goal was to understand how psychological strategies affect …

This study looked at how 8 healthy adults coped emotionally during a 120-km ultra-endurance race. Researchers measured defense mechanisms and emotional regulation before and during the race, along with physical and mental fatigue. The goal was to understand how these psychologica…

This completed study compared two preoxygenation techniques—non-invasive ventilation alone versus non-invasive ventilation combined with high-flow nasal oxygen—in 30 healthy volunteers. Researchers monitored oxygen levels in the breath and blood over 3-minute sessions to see whic…

This study tested whether a hospital pharmacist's interview could reduce unplanned doctor visits or hospital stays for adults with lung cancer receiving chemotherapy, immunotherapy, or oral targeted therapy. Researchers tracked 60 patients over six months, counting unscheduled co…

This study tested whether a near-infrared light device helps nurses insert a peripheral IV line on the first try in intensive care patients who have arm swelling. 380 adults with a central line that was no longer needed took part. The device uses light to show veins under the ski…

This study looked at brain activity in 29 healthy, right-handed adults during real hand movements and during the illusion of movement caused by tendon vibration. Researchers repeated each task 20 times to find out the fewest repetitions needed to get clear brain signals. The goal…

This study followed 187 people who had COVID-19 to see how their antibody levels changed over 24 months. Researchers took blood samples and, in some cases, nasal swabs to measure both general and neutralizing antibodies. They also looked at how the severity of the initial infecti…

This study looked at whether taking out the nasogastric feeding tube right after removing a breathing tube helps ICU patients start eating by mouth sooner. Swallowing problems are common after ICU stays, and the feeding tube itself might delay recovery. 112 adults who had been on…

This study looked at 175 critically ill adults who needed to be moved within the hospital while on high-flow nasal oxygen. The goal was to see how often serious problems like low oxygen or needing a breathing tube happened during transport. The findings could help make these move…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This study looked at whether a specific serotonin receptor, called 5-HT7, could be used as a biomarker for multiple sclerosis (MS). Researchers measured the receptor on different blood cells from 100 people, including those with MS and healthy volunteers. The goal was to better u…

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …