Scientists track COVID antibodies for two years to unlock immunity secrets

NCT ID NCT04750720

Completed Knowledge-focused Sponsor: Centre Hospitalier Régional d'Orléans Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 187 people who had COVID-19 to see how their antibody levels changed over 24 months. Researchers took blood samples and, in some cases, nasal swabs to measure both general and neutralizing antibodies. They also looked at how the severity of the initial infection and vaccination affected antibody persistence. The goal is to better understand long-term immunity after COVID-19.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors predict how long COVID-19 immunity lasts and tailor vaccine schedules based on infection severity.
What could go wrong: This is an observational study, not a treatment trial. It only measures antibodies, which may not fully reflect protection. Results may not apply to new virus variants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19 SARS COV-2

Contacts and locations

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Locations

CHU Orléans

Orléans, 45067, France

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