New drug GEn-1124 tested for severe lung failure

NCT ID NCT05795465

Recruiting now Disease control Sponsor: GEn1E Lifesciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called GEn-1124 in 52 adults with acute respiratory distress syndrome (ARDS), a severe lung condition. The drug is given as an IV infusion twice daily for 5 days, starting as soon as possible after diagnosis. The main goal is to check if the drug is safe and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GEn-1124 (given as an intravenous infusion)
What this could lead to: If successful, this could point toward a new treatment to help control severe lung inflammation in ARDS patients.
What could go wrong: This is an early Phase 2 trial with only 52 participants, so results may not apply to all ARDS patients. The main goal is safety, not yet proven effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY DISTRESS SYNDROME, ACUTE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cooper University Hospital
RECRUITING

Camden, New Jersey, 08103, United States
Houston Methodist Hospital
WITHDRAWN

Houston, Texas, 77030, United States
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
Medstar Washington Hospital Center
WITHDRAWN

Washington D.C., District of Columbia, 20010, United States
Ocean Springs Hospital
COMPLETED

Ocean Springs, Mississippi, 39564, United States
The Mount Sinai Hospital
WITHDRAWN

New York, New York, 10029, United States
University of Kansas Medical Center
WITHDRAWN

Kansas City, Kansas, 66160, United States
University of Maryland - Baltimore Washington Medical Center
RECRUITING

Glen Burnie, Maryland, 21061, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21201, United States
Washington University School of Medicine
WITHDRAWN

St Louis, Missouri, 63110, United States