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Could a lung scarring drug help ARDS patients breathe easier?

NCT ID NCT05075161

Recruiting now Disease control Sponsor: Università Vita-Salute San Raffaele Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether pirfenidone, a drug already used for a different lung disease, can prevent scarring in patients with severe acute respiratory distress syndrome (ARDS). About 130 people on ventilators will receive either pirfenidone or a placebo through a feeding tube. The goal is to see if the drug helps them spend fewer days on a ventilator and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Pirfenidone
What this could lead to
If it works, this could provide a new treatment to prevent long-term lung damage in patients with severe respiratory failure.
What could go wrong
This is an early test in humans for ARDS, so the drug may not work as hoped. Side effects from pirfenidone, like nausea or liver issues, are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)

Contacts and locations

Locations

  • A.O.R San Carlo

    RECRUITING

    Potenza, Italy

  • AOU Città della Salute e della Scienza

    RECRUITING

    Torino, 10126, Italy

  • AOU Pisana

    RECRUITING

    Pisa, Italy

  • AOU Policlinico Paolo Giaccone

    RECRUITING

    Palermo, Italy

  • ASST Spedali Civili di Brescia

    RECRUITING

    Brescia, 25123, Italy

  • Astana Medical University

    RECRUITING

    Astana, 010000, Kazakhstan

  • Azienda Ospedaliero Universitaria Pisana

    RECRUITING

    Pisa, 56126, Italy

  • Azienda Ospedaliero Universitaria Senese

    RECRUITING

    Siena, 53100, Italy

  • Azienda Sanitaria Universitaria Integrata di Udine

    RECRUITING

    Udine, 33100, Italy

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    RECRUITING

    Milan, Italy

  • Fondazione PTV - Policlinico Tor Vergata

    RECRUITING

    Rome, 00133, Italy

  • IRCCS San Raffaele Scientific Institute

    RECRUITING

    Milan, MI, 20132, Italy

  • Ospedale Cesare Arrigo

    RECRUITING

    Alessandria, Piedmont, 15121, Italy

  • Ospedale San Giovanni di Dio - Azienda Ospedaliera Universitaria di Cagliari

    RECRUITING

    Cagliari, 09123, Italy

  • Ospedale Santa Maria

    RECRUITING

    Bari, Italy

  • Ospedale Uboldo di Cernusco sul Naviglio

    RECRUITING

    Milan, 20070, Italy

  • Ospedale di Merano

    RECRUITING

    Merano, Italy

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