Adult acute respiratory distress syndrome
MONDO:0100130A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%.
Also known as: adult ARDS, adult acute respiratory distress syndrome, adult respiratory distress syndrome, adult respiratory distress syndrome, ARDS, respiratory distress syndrome, adult, ARDS
264 clinical trials for this condition and its sub-types.
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Could a second dose of steroids help premature babies breathe easier?
Disease control TerminatedThis study investigates whether giving a repeat course of betamethasone, a steroid, to pregnant women with preterm premature rupture of membranes (PPROM) can improve health outcomes for their premature babies. The main goal is to see if it shortens the baby's stay in the neonatal…
Phase: PHASE2, PHASE3 • Sponsor: The University of Texas Medical Branch, Galveston • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Heart drug fails to prove benefit for lung failure patients in early-stop trial
Disease control TerminatedThis study tested whether giving the heart medication metoprolol through a vein could help people with severe lung failure (ARDS) in the ICU. The goal was to see if it helped them breathe without a machine for more days. However, the trial was stopped early and only 14 people too…
Phase: PHASE3 • Sponsor: Consorcio Centro de Investigación Biomédica en Red (CIBER) • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Carbon monoxide as medicine? tiny trial tests inhaled gas for lung failure
Disease control TerminatedThis early-phase trial tested whether inhaling low doses of carbon monoxide could be safe for people with severe lung injury caused by sepsis. Only 5 participants were enrolled before the study was stopped early. The goal was to see if a personalized dosing formula could safely a…
Phase: PHASE1 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Could a simple gas stop COVID-19 from getting worse?
Disease control TerminatedThis study tested whether breathing in nitric oxide gas could keep mild-to-moderate COVID-19 from becoming severe. Researchers enrolled 62 hospitalized adults who were breathing on their own. The goal was to see if the gas reduced the need for a breathing tube. The trial was stop…
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Personalized ventilation for ARDS: early trial halted, results uncertain
Disease control TerminatedThis study tested whether setting a ventilator based on each patient's lung volume could improve outcomes for people with moderate-to-severe acute respiratory distress syndrome (ARDS). The approach used a bedside measurement to tailor the pressure applied during breathing. Howeve…
Phase: PHASE3 • Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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New ventilation technique tested in ICU patients with severe lung failure
Knowledge-focused TerminatedThis trial tested a new way of using a breathing machine (flow-controlled ventilation) against the standard method (pressure-controlled ventilation) in 15 ICU patients with moderate to severe acute respiratory distress syndrome (ARDS). The goal was to see if the new method uses l…
Phase: NA • Sponsor: Erasmus Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Brain injury and ARDS: which breathing maneuver is safer?
Knowledge-focused TerminatedThis study compared two breathing techniques (CPAP and eSigh) in 18 patients with brain injury and acute respiratory distress syndrome (ARDS). The goal was to see which method better maintains oxygen levels in the brain without causing harm. The trial was terminated early, so fin…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Tiny study on lung support in ARDS halted early
Knowledge-focused TerminatedThis study aimed to compare two ways of setting breathing machine pressure (PEEP) in patients with severe lung injury (ARDS). The goal was to see which method better protects the lungs and heart. Only 2 patients were enrolled before the study was stopped, so no meaningful results…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Scientists probe immune cells in pneumonia to unlock ARDS secrets
Knowledge-focused TerminatedThis study looked at how certain immune cells, called non-conventional T cells, behave in patients with severe pneumonia and acute respiratory distress syndrome (ARDS). Researchers collected blood and airway samples from 258 intensive care unit patients to track these cells over …
Sponsor: University Hospital, Tours • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Smart band tracks COVID-19 breathing trouble
Knowledge-focused TerminatedThis study tested a special band called AirGo to monitor breathing patterns in hospitalized COVID-19 patients with respiratory failure. The goal was to see if the band could detect early signs of worsening breathing, helping doctors decide when to use a breathing tube. The study …
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC