Adult acute respiratory distress syndrome

This study looks at two different ways to use ventilators for children with acute respiratory distress syndrome (ARDS), a serious lung condition. The goal is to see which method helps children recover faster and breathe better. About 160 children will take part, and the results w…

This trial tests whether adding gentle oscillations to standard nasal continuous positive airway pressure (NCPAP) improves breathing support for newborns with respiratory distress syndrome. Premature infants who need NCPAP will be randomly assigned to receive either oscillatory N…

This study tests a non-invasive pneumatic vest designed to apply pressure to the chest wall in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 who are on mechanical ventilators. The goal is to see if the vest can improve oxygen levels in the blood. Up …

This study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study was designed to test whether adding an experimental drug and special immune cells to standard care could help critically ill adults with severe pneumonia, especially those with sepsis or lung failure. The trial was withdrawn before enrolling any participants, so no res…

This study was designed to see if adding two immune treatments (NAI and iNKT cells) to standard care could help critically ill adults with severe pneumonia, sepsis, or lung failure recover. It planned to enroll ICU patients and follow them for 90 days. However, the study was with…

This study looks at whether a step-by-step care plan (called TheraPPP) helps patients with severe breathing failure (ARDS) survive and spend less time on a ventilator. The plan includes proven treatments like protective ventilation, paralysis, and prone positioning. About 20,000 …

This study compares two breathing support strategies—prone positioning and high-frequency ventilation—against standard care in 600 children with severe acute respiratory distress syndrome. The goal is to see which approach helps children spend more days off a ventilator within 28…

This study was designed to test whether IC14, a drug that blocks a key inflammatory signal, could help people with acute respiratory distress syndrome (ARDS). The plan was to give IC14 or a placebo to about 100 ICU patients and see if it reduced time on a ventilator. However, the…

This Phase 3 trial tests whether adding budesonide (an anti-inflammatory) to standard surfactant treatment helps extremely preterm babies avoid chronic lung disease or death. About 642 infants born before 29 weeks or weighing under 1000 grams will receive either the combo or surf…

This study tests several experimental treatments at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the h…

This study planned to test whether putting a thyroid hormone (T3) directly into the lungs could help people with severe COVID-19 who need a breathing machine. The goal was to reduce fluid in the lungs and shorten time on a ventilator. However, the trial was withdrawn before any p…

This early-stage study aimed to test whether infusing donor stem cells could help people recover from acute respiratory distress syndrome (ARDS) caused by COVID-19. The trial was withdrawn before enrolling any participants, so no results are available. The approach was based on e…

This study planned to test a new stem cell product (BX-U001) in people with severe COVID-19 pneumonia and moderate to severe lung failure (ARDS). The goal was to check safety and find the best dose. However, the study was withdrawn before enrolling any participants, so no results…

This study tests a single dose of an antibody called ALT-100 in people with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. The trial involves 15 hospitalized adults and compares the drug to a placebo. The main goal is to check sa…

This trial tests whether a single infusion of stem cells from donated umbilical cords can help people with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in intensive care. The study first finds a safe dose, then randomly gives either stem cells or…

This study tests whether giving a thyroid hormone (T3) directly into the lungs can safely improve oxygen levels in adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 68 critically ill patients on ventilators will either receive the hormone or s…

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO…

This study investigates cognitive problems in intensive care patients with acute respiratory distress syndrome (ARDS) who develop delirium (sudden confusion). Researchers use a non-invasive EEG cap and auditory tests to measure brain activity at the bedside. The goal is to identi…

This study follows 200 adults on ECMO (a heart-lung machine) for severe breathing problems. Researchers track how many get hospital-acquired infections and measure antibiotic levels in their blood and lungs. The goal is to learn more about infections and drug dosing in these crit…

This study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …

This study tests whether a drug called racecadotril can reduce fluid leakage in skin blisters, as a model for what happens in the lungs during Acute Respiratory Distress Syndrome (ARDS). ARDS is a severe lung injury with no effective drug treatments, where patients' lungs fill wi…

This study follows 120 adults with moderate-to-severe ARDS who are on a breathing machine. Researchers use a non-invasive belt (electrical impedance tomography) to track how air and blood flow are distributed in the lungs over time. The goal is to see if different lung function p…

This study looks at babies born to mothers with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes itching and high bile acid levels. Researchers want to see if these bile acids can lead to breathing problems in newborns. They will compare 120 babies—some …

This study follows 200 ICU patients with severe COVID-19 to see how often they develop lung scarring (pulmonary fibrosis). Researchers will use blood tests and CT scans to find early signs of scarring and identify risk factors. The goal is to understand how scarring affects recov…

This study looks at how well medical teams follow safety guidelines when treating people hurt in a chemical, biological, or nuclear attack. Researchers will track 1,000 patients to see if care is given without delay and if contamination is controlled during rescue. The goal is to…