One-Size-Fits-All oxygen may be outdated: new trial tests personalized targets

NCT ID NCT07536984

ENROLLING_BY_INVITATION Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial involves 3,000 adults in intensive care units at Vanderbilt.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized SpO2 target (oxygen level goal)
What this could lead to: If it works, this could show that tailoring oxygen levels to each patient improves survival and reduces time on a ventilator.
What could go wrong: This is an early-stage study testing a new approach. The personalized targets are based on a statistical model, which may not work for everyone. There is also a risk that the model's recommendations could lead to worse outcomes in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY FAILURE

Contacts and locations

Locations

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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