New trial aims to slash COVID-19 deaths and ventilator use

NCT ID NCT04488081

Ongoing Disease control Sponsor: QuantumLeap Healthcare Collaborative Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests several experimental treatments at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the hospital are participating.

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome COVID-19 disease respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Locations

Columbia University Medical Center

New York, New York, 10032, United States
Corewell Health

Grand Rapids, Michigan, 49503, United States
DHR Health

Edinburg, Texas, 78539, United States
Emory University

Atlanta, Georgia, 30322, United States
Georgetown University

Washington D.C., District of Columbia, 20007, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Kaiser LAMC

Los Angeles, California, 90027, United States
Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States
Lankenau Medical Center (Mainline Health)

Wynnewood, Pennsylvania, 19096, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Long Beach Memorial Medical Center

Long Beach, California, 90806, United States
Main Line Health - Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
Northwestern University

Chicago, Illinois, 60611, United States
Sanford Health

Souix Falls, South Dakota, 57109, United States
Stamford Health

Stamford, Connecticut, 06904, United States
UC Davis Medical Center

Davis, California, 95817, United States
UC Irvine Medical Center

Irvine, California, 92868, United States
University Hospital Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California San Francisco (UCSF)

San Francisco, California, 94115, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Florida

Gainesville, Florida, 32608, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Miami

Coral Gables, Florida, 33124, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania (U Penn)

Philadelphia, Pennsylvania, 19104, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Southern California

Los Angeles, California, 90033, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Virtua Mount Holly Hospital

Mount Holly, New Jersey, 08060, United States
Virtua Voorhees Hospital

Voorhees Township, New Jersey, 08043, United States
WVU Medicine

Morgantown, West Virginia, 26506, United States
Wake Forest Baptist Comprehensive Cancer Center

Winston-Salem, North Carolina, 27157, United States
Yale Cancer Center

New Haven, Connecticut, 06510, United States

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