Adult acute respiratory distress syndrome

This phase II trial tested whether inhaling low doses of carbon monoxide (200 ppm for 90 minutes daily for 3 days) is safe and helpful for people with acute respiratory distress syndrome (ARDS), a severe lung condition. Only 4 intubated adults participated, making this a very sma…

This Phase 2 trial tested whether adding reparixin, an anti-inflammatory drug, to standard care could improve lung function in adults with moderate to severe acute respiratory distress syndrome (ARDS). The study enrolled 66 patients on mechanical ventilators. Researchers measured…

This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating peri…

This clinical trial tested a drug called sivelestat sodium in 324 adults with acute respiratory distress syndrome (ARDS) and systemic inflammation. The drug aims to block a harmful enzyme that damages lung tissue. Researchers measured whether it improved oxygen levels and reduced…

This early-stage study tested a single dose of mesenchymal stromal cells in 7 COVID-19 patients with severe acute respiratory distress syndrome (ARDS) who were on ventilators. The main goal was to check safety, looking for serious side effects like heart problems or blood clots w…

This study tested whether inhaling sevoflurane, a gas usually used for anesthesia, for the first 48 hours could improve oxygen levels and reduce inflammation in 50 adults with moderate to severe ARDS. Participants were randomly assigned to receive either sevoflurane or a standard…

This study tested whether using sevoflurane (an inhaled anesthetic) for sedation could lower death rates and shorten time on a ventilator in patients with acute respiratory distress syndrome (ARDS). 700 adults were randomly assigned to receive either sevoflurane or standard propo…

This study tested whether a single dose of stem cells (mesenchymal stromal cells) could help patients with severe COVID-19 lung inflammation breathe better. Twenty adults with confirmed COVID-19 and acute respiratory distress syndrome were randomly assigned to receive either the …

This completed study tested a breathing machine strategy that uses lung pressure measurements to guide settings, aiming to protect the right side of the heart in patients with acute respiratory distress syndrome (ARDS). Forty adults on ventilators for less than 72 hours were incl…

This study looked at 85 very premature babies (24-29 weeks) with breathing problems to compare two types of non-invasive breathing support: nasal CPAP and nasal IPPV. Both methods deliver surfactant (a lung treatment) without a breathing tube. The goal was to see which method red…

This study tested whether using a special imaging technique (EIT) to set breathing machine pressure helps people with severe lung injury (ARDS) survive longer compared to using a standard pressure table. Over 600 adults on breathing machines took part. The main goal was to see if…

This completed study tested a technique called continuous anterior chest compression (CACC) in 20 adults with moderate to severe acute respiratory distress syndrome (ARDS). The goal was to see if manually pressing on the chest could improve how air and blood move through the lung…

This study tested a method called LISA (Less Invasive Surfactant Administration) in extremely preterm infants (22-25 weeks). Instead of inserting a breathing tube, doctors gave lung medication through a thin catheter while the baby continued on CPAP. The goal was to see if this a…

This phase II study tested an injectable drug called TISA-818-Inj in 57 adults with acute respiratory distress syndrome (ARDS), a severe lung condition. Participants received either a low dose, a high dose, or a placebo for 14 days. The main goal was to check safety, with seconda…

This early-stage trial tested a new cell therapy called agenT-797 in 20 hospitalized COVID-19 patients with moderate to severe breathing distress. The therapy uses immune cells from a healthy donor to calm inflammation and fight the virus. The main goals were to check safety and …

This study looked at 100 premature babies (26-36 weeks) with respiratory distress syndrome who didn't improve with standard nasal CPAP. Researchers compared a newer, non-invasive high-frequency ventilation method (nHFOV) with traditional mechanical ventilation. The goal was to se…

This study looked at 180 premature babies born between 24 and 30 weeks to see if giving lung medication (surfactant) through a thin tube (LISA method) could reduce the need for a breathing tube in the first three days of life, compared to standard CPAP alone. The goal was to find…

This study tested whether placing patients with severe acute respiratory distress syndrome (ARDS) face down (prone) for at least 16 hours a day could lower their risk of dying. 474 adults on ventilators were randomly assigned to prone or standard (semi-recumbent) positioning. The…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This study tested whether a single infusion of stem cells from donor bone marrow could help people with acute respiratory distress syndrome (ARDS), a severe lung condition. 120 adults on ventilators received either stem cells or a placebo. Researchers measured changes in oxygen l…

This study tested whether using a special antiseptic dressing on ECMO tubes can reduce serious infections in critically ill patients. About 270 adults on ECMO for heart or lung failure were randomly assigned to get either the special dressing or a standard one. The goal was to se…

This study tested whether filtering the blood (therapeutic plasma exchange) could help severe COVID-19 patients by removing harmful immune molecules that cause lung damage. Twenty-one adults in intensive care with COVID-19 and lung failure were randomly assigned to receive either…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study looked at whether a special ultrasound technique called fetal lung elastography can predict respiratory distress syndrome (RDS) in preterm babies. Researchers measured lung stiffness in 80 unborn babies between 24-33 weeks of pregnancy and compared those who later deve…

This study looked at 277 ICU patients on breathing machines to see how well chest X-rays (read by intensive care doctors) agreed with CT scans (read by radiologists) for diagnosing acute respiratory distress syndrome (ARDS). The results showed only fair agreement, meaning X-rays …

This study looked at whether a quick diaphragm ultrasound in the emergency room can predict which patients with severe breathing problems will need a ventilator within the first four hours. Researchers measured diaphragm movement in 104 adults upon arrival and again four hours la…

This study tested a new MRI technique that can take pictures of children's lungs without using radiation or injecting contrast dye. 72 children aged 6-16 had both a standard CT scan and this new MRI. The goal was to see if the MRI could produce clear images of the lungs, potentia…

This pilot study tested a non-invasive device that stimulates the vagus nerve (nVNS) in patients hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if adding nVNS to standard care could prevent severe lung inflammation and the need for a breathing mach…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of…

This study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…

This study tested freezing the nerves between the ribs during robot-assisted lung surgery to see if it reduces pain and the need for painkillers afterward. 33 adults having lung surgery were randomly assigned to get the nerve freeze or standard pain medicine. Researchers tracked …

This study looked at two different chest therapy methods—Vojta reflex and lung squeezing—to help premature babies (28-36 weeks) with breathing problems. 90 babies were split into three groups: one got standard care, the others got standard care plus one of the two extra technique…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study looked at 80 children aged 1 month to 5 years with severe breathing problems from pneumonia or bronchiolitis. It compared two non-invasive breathing support methods: High Velocity Nasal Insufflation (HVNI) and Nasal Continuous Positive Airway Pressure (CPAP). The goal …

This study tested whether having conscious COVID-19 patients with breathing problems lie face down (prone position) while on high-flow oxygen could reduce the need for a breathing tube. Over 400 adults with COVID-19 pneumonia and mild to severe acute respiratory distress syndrome…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who survived severe COVID-19 recover more quickly. Twenty-two patients who had been on ventilators in the ICU took part in a 4-week rehab program. Half did cycling with FES,…

This study tested whether a computer-driven system called Smartcare/PS could help children with respiratory failure come off a breathing machine faster than usual care. Thirty children were enrolled, and the system automatically adjusted breathing support based on each child's ne…

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…

This study looked at 60 premature newborns (born between 28-37 weeks) in the neonatal intensive care unit who had breathing problems or were on a ventilator. Researchers compared different chest physiotherapy methods and positions to see which worked best for clearing the lungs. …

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at 20 patients who have both high pressure in their belly (intra-abdominal hypertension) and severe lung injury (ARDS). Researchers will compare two methods for setting the ventilator's positive end-expiratory pressure (PEEP): one based on lung pressure measureme…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the foc…

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This study looked at 136 premature babies who needed breathing help. Researchers tracked how long they needed support and checked for lung problems. The goal was to learn more about different non-invasive breathing methods, not to test a new treatment.

This study looked at the experiences of 126 people in Denmark who rely on a breathing machine at home, along with their families and the trained caregivers who help them. The goal was to understand the challenges and successes of this life-sustaining care. No new treatments were …

This study looked at ways to improve the care, environment, and daily routines of children in the pediatric intensive care unit (PICU) to support their healing and natural sleep-wake cycles. Researchers observed 56 children aged 6 months to 18 years who were on breathing machines…

This study looked at 10 adults with moderate-to-severe ARDS who were on breathing machines. Researchers used a non-invasive imaging method (EIT) to adjust ventilator pressure settings and then checked how the heart's right side responded using ultrasound. The goal was to find the…

This study looked at 500 adults on breathing machines to see if measuring airway pressure at a specific moment (P1) versus a later moment (P2) better predicts lung damage. The goal is to find which measurement helps doctors set safer ventilator settings. No new treatment was test…

This study checks on 137 COVID-19 patients who were in the ICU and used awake prone positioning (lying on their belly) while on high-flow oxygen. Researchers want to see if this technique affects quality of life and survival more than two years later. Participants answer a phone …

This study observed over 4,000 patients in Chinese ICUs who needed breathing support for acute respiratory failure. Researchers tracked treatments, outcomes, and costs to better understand the disease burden. The goal is to improve care and identify risk factors, not to test a ne…

This study followed 38 children who survived acute respiratory distress syndrome (ARDS), a severe lung condition. One year after leaving the hospital, researchers checked for lasting breathing problems like cough, wheeze, and lung stiffness using scans and tests. The goal was to …

This study tested whether a special imaging method called electrical impedance tomography (EIT) can help doctors choose the best ventilator settings for patients with severe lung injury (ARDS). The goal was to see if EIT could identify which patients would benefit from higher or …

This study tested whether a miniaturized ultrasound probe placed in the esophagus could help predict outcomes in 50 patients with acute respiratory distress syndrome (ARDS). The probe measures a blood vessel collapse index that may indicate heart strain. Researchers tracked how m…

This study looked at 513 children with a severe lung condition called ARDS to find different subtypes of the disease. Researchers collected blood samples to measure proteins and gene activity. The goal was to better understand the disease and help design more targeted treatments …

This study looked at 93 people with lung disease who get short of breath when active. Participants did two 6-minute walk tests: one at their fastest pace and one at their normal walking speed. The goal was to see if the normal-speed test gives a more accurate picture of when they…

This study looked at a new way to set breathing machines for people with severe lung injury (ARDS). The method uses pressure measurements inside the lungs to adjust settings. Nine adults took part to see if the approach is safe and works well. The goal was to learn more, not to c…

This study reviewed medical records of over 640,000 people in the US who had acute respiratory distress syndrome (ARDS) and were in the ICU. Researchers wanted to find out what new health problems—physical, mental, or emotional—arise after such a stay, known as post-intensive car…

This study looked at whether a blood test measuring suPAR levels can predict which adults hospitalized with COVID-19 will develop severe breathing failure requiring a breathing tube. Researchers analyzed stored blood samples from about 367 patients. The goal was to see if a suPAR…

This study looked at how the pressure used in mechanical ventilators affects the right side of the heart in people with acute respiratory distress syndrome (ARDS). Researchers measured lung pressure and heart function in 50 adults and children. The goal was to find out if high lu…

This pilot study tested three common ventilator modes—volume control, pressure control, and adaptive pressure control—in 566 ICU adults with respiratory failure. The goal was to see which mode leads to more days alive and off the ventilator. The study is a first step to guide fut…

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…

This study tested whether a simple video call system on a tablet could help doctors remotely assess children with breathing problems while they were being transported in an ambulance. Researchers worked with 20 children who were stable enough for transport and compared the remote…

This study tested a new way to measure pain in preterm infants during a procedure called LISA, where surfactant is given to help them breathe. Researchers used skin conductance, which tracks nerve signals, and compared it to a standard pain scale. The goal was to see if this meth…

This study examined over 1,200 adults admitted to an intensive care unit to see if the reason they were admitted (like sepsis or breathing failure) could predict their risk of dying in the ICU, beyond what standard severity scores show. Researchers looked back at medical records …

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This study looked at whether measuring tiny brain signals during a breathing test can help predict if a patient on a ventilator will successfully breathe on their own. Researchers monitored 70 intubated adults as they tried breathing without the machine. The goal is to find a sim…

This study tested whether having a dietitian help patients with lung disease order meals during a hospital stay could improve their nutrition and reduce the chance of being readmitted after discharge. 41 patients at nutritional risk took part. Researchers measured daily food inta…

This study looked at a new way to measure airway closure in patients with severe lung injury (ARDS) who are on breathing machines in the ICU. Researchers tested a simple method to see if the lungs are trapping air, which can help doctors adjust ventilator settings. The study invo…

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This study looked at 73 people who were hospitalized with severe COVID-19 pneumonia to see if their lungs still had problems 4 months later. The main focus was on how well oxygen moves from the lungs into the blood. The goal was to better understand these lasting issues so doctor…

This study surveyed 534 physicians worldwide to understand how they use humidification (adding moisture to air) when treating hospitalized adults with non-invasive ventilation (breathing support through a mask). The goal was to find out how often humidification is used, what type…

This study looked at whether two different doctors can get the same diaphragm measurements using ultrasound in patients with severe breathing problems in the emergency room. 26 adults with acute respiratory distress were each scanned twice by two separate investigators. The goal …

This study looked at 24 critically ill patients on breathing machines to see how changing the machine's settings affects measurements of breathing effort. Researchers compared a simple bedside measurement with a more invasive gold-standard technique. The goal was to find the best…

This study looked at 60 adults with acute respiratory distress syndrome (ARDS) on breathing machines. It compared two ventilation methods—airway pressure release ventilation (APRV) and low tidal volume (LTV) ventilation—to see which one better protects the right side of the heart…

This study looked at whether the angle of a patient's head (flat at 0° or raised at 30°) changes the esophageal pressure reading used to set ventilators. Eleven adults with acute respiratory distress syndrome (ARDS) had their pressures measured in both positions. The goal was to …

This study looked at 32 adults with severe lung injury (ARDS) who were placed face-down (prone) to help them breathe. Researchers measured pressure inside the lungs using a small balloon in the esophagus. They wanted to see if the face-down position changes lung pressure enough t…

This study looked at 94 adults with acute respiratory distress syndrome (ARDS) who needed a breathing tube and were placed on their stomachs (prone position). Researchers used a non-invasive imaging tool called electrical impedance tomography (EIT) to measure how air and blood fl…