Gentler lung treatment may help preterm babies avoid breathing tubes

NCT ID NCT04209946

Completed Disease control Sponsor: Sharp HealthCare Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 180 premature babies born between 24 and 30 weeks to see if giving lung medication (surfactant) through a thin tube (LISA method) could reduce the need for a breathing tube in the first three days of life, compared to standard CPAP alone. The goal was to find a gentler way to support breathing and avoid more invasive procedures. Results will help doctors choose the best approach for these fragile infants.

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome newborn respiratory distress syndrome Premature Birth Pulmonary Atelectasis respiratory distress syndrome in premature infants

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREMATURE LUNGS RESPIRATORY DISTRESS SYNDROME SURFACTANT DEFICIENCY SYNDROME NEONATAL

Contacts and locations

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Locations

Loma Linda Medical Center

Loma Linda, California, 92350, United States
Sharp Mary Birch Hospital for Women & Newborns

San Diego, California, 92123, United States
University of California, Irvine

Irvine, California, 92868, United States