Personalized ventilation for ARDS: early trial halted, results uncertain
NCT ID NCT04012073
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether setting a ventilator based on each patient's lung volume could improve outcomes for people with moderate-to-severe acute respiratory distress syndrome (ARDS). The approach used a bedside measurement to tailor the pressure applied during breathing. However, the trial was stopped early after enrolling only 18 participants, so it is not possible to draw firm conclusions about its effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Invasive mechanical ventilation with individualized positive end-expiratory pressure (PEEP) guided by end-expiratory lung volume (EELV) measurement
What this could lead to
If successful, this approach could help doctors set ventilators more precisely for each ARDS patient, potentially reducing lung injury and improving survival.
What could go wrong
The trial was terminated early with only 18 participants, so results are very limited. It is unclear if the method works better than standard care, and any benefits remain unproven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azienda ospedaliera universitaria di Ferrara-arcispedale Sant'Anna
Ferrara, Italy
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Azienda ospedaliero-universitaria Mater Domini
Catanzaro, Italy
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Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
Milan, Italy
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Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
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Fondazione Policlinico Universitaro A. Gemelli IRCCS
Rome, Italy
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Ospedale San Gerardo
Monza, Italy
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Ospedale San Martino
Genova, Italy
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Policlinico Sant'Orsola
Bologna, Italy
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Policlinico di Bari
Bari, Italy
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SS. Annunziata hospital
Chieti, Italy