Personalized ventilation for ARDS: early trial halted, results uncertain
NCT ID NCT04012073
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether setting a ventilator based on each patient's lung volume could improve outcomes for people with moderate-to-severe acute respiratory distress syndrome (ARDS). The approach used a bedside measurement to tailor the pressure applied during breathing. However, the trial was stopped early after enrolling only 18 participants, so it is not possible to draw firm conclusions about its effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Invasive mechanical ventilation with individualized positive end-expiratory pressure (PEEP) guided by end-expiratory lung volume (EELV) measurement
- What this could lead to
- If successful, this approach could help doctors set ventilators more precisely for each ARDS patient, potentially reducing lung injury and improving survival.
- What could go wrong
- The trial was terminated early with only 18 participants, so results are very limited. It is unclear if the method works better than standard care, and any benefits remain unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE RESPIRATORY DISTRESS SYNDROME are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Azienda ospedaliera universitaria di Ferrara-arcispedale Sant'Anna
Ferrara, Italy
-
Azienda ospedaliero-universitaria Mater Domini
Catanzaro, Italy
-
Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
Milan, Italy
-
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
-
Fondazione Policlinico Universitaro A. Gemelli IRCCS
Rome, Italy
-
Ospedale San Gerardo
Monza, Italy
-
Ospedale San Martino
Genova, Italy
-
Policlinico Sant'Orsola
Bologna, Italy
-
Policlinico di Bari
Bari, Italy
-
SS. Annunziata hospital
Chieti, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Lung-Opening maneuver change a key injury marker in ARDS?
- Could simply sitting up ease breathing in severe lung failure?
- Could lung fluid proteins reveal a new way to track severe lung injury?
- Could a spirometer test guide breathing support in respiratory failure?
- Which ventilator setting saves more lungs? a Head-to-Head test
- Can a single antibody turn down the immune storm in ARDS?