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Simple breath test may guide fluid therapy for shock patients

NCT ID NCT04023786

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a simple method to see if giving extra fluids would help patients on breathing machines who are in shock. Doctors used a short increase in breathing machine pressure (PEEP test) to predict fluid needs. The goal was to avoid unnecessary fluids. The study involved 66 adults in the hospital.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Dec 2019

Finished

Jul 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Coverage by a health insurance scheme * Patient under mechanical invasive ventilation (tracheal intubation) * PEEP level ≥10 cmH2O * Cardiac flow monitoring device in place by the PiCCO2 system (Pulsion Medical Systems, Feldkirch, Germany). * Ikorus urinary catheter in place * Decision by the doctors in charge of carrying out a passive leg raising test and / or a volume expansion Exclusion Criteria: * Pregnancy * Participation in another interventional study * Patients under the protection of justice * Thoracic drainage (preventing PEP changes from inducing intrathoracic and transpulmonary pressure changes from their hemodynamic effects).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation

Contacts and locations

Locations

  • Dr Alexandra Beurton

    Le Kremlin-Bicêtre, Val de Marne, France

  • Dr Alexandra Beurton

    Paris, 75651, France

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