Could a Ketamine-Like drug improve sedation for sepsis patients on life support?
NCT ID NCT07556172
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests esketamine, a drug related to ketamine, for sedation and delirium prevention in 80 septic patients who need a breathing tube. The goal is to see if esketamine can reduce time on the ventilator and improve survival compared to standard sedatives. The trial is active but no longer recruiting participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Esketamine
What this could lead to
If successful, esketamine could offer a safer sedation option for septic patients on ventilators, potentially reducing delirium and improving outcomes.
What could go wrong
This is a small, single-center phase 4 trial with only 80 participants. Esketamine's benefits for this specific use are unproven, and side effects like hallucinations or blood pressure changes are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330000, China