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Could slower breathing on ventilators save lungs? small study aims to find out

NCT ID NCT07077174

Recruiting now Knowledge-focused Sponsor: Reinier de Graaf Groep Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This pilot study tests whether using a lower breathing rate on ventilators is safe and practical for critically ill patients. About 56 adults on breathing machines will be randomly assigned to either the new lower-rate approach or standard care. The goal is to see if the new method can be used without causing harm, which would then allow a larger trial to test if it improves patient outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
permissive lung-protective ventilation (a ventilator setting with a lower breathing rate)
What this could lead to
If successful, this could pave the way for a larger trial that may show a better way to ventilate ICU patients, potentially reducing lung damage.
What could go wrong
This is a small, early pilot study with only 56 patients. It is designed to test feasibility and safety, not effectiveness, so it may not lead to changes in practice.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HYPOXEMIC RESPIRATORY FAILURE INTENSIVE CARE (ICU) MECHANICAL VENTILATION

Contacts and locations

Locations

  • Amsterdam UMC

    RECRUITING

    Amsterdam, Netherlands

  • Dijklander Hospital

    RECRUITING

    Hoorn, Netherlands

  • Reinier de Graaf Hospital

    RECRUITING

    Delft, Netherlands

  • Vall d'Hebron

    RECRUITING

    Barcelona, Spain

  • ZiekenhuisGroep Twente

    RECRUITING

    Almelo, Netherlands

    Contact Email: •••••@•••••

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