Perinatal disease

Thick meconium in the amniotic fluid affects about 1 in 7 pregnancies and can cause breathing problems in newborns. The PEARL trial tests whether infusing warm sterile fluid into the uterus during labor reduces these risks. The study will enroll 320 pregnant people at 36 weeks or…

This study tests whether a 'maternity care home' — combining prenatal checkups with social services like housing and food help — can lower the risk of severe complications in Black, Indigenous, Asian, and Latina pregnant patients. About 2,300 participants will be randomly assigne…

This study looks at a fetal surgery called FETO for babies with a severe diaphragmatic hernia, where organs move into the chest. The surgery places a balloon in the baby's windpipe to help the lungs grow, then removes it before birth. Researchers will compare 40 babies who get FE…

This study tests whether adding a filter to the IV lines of newborns in intensive care can reduce infections and inflammation. Tiny particles in IV fluids may harm babies, and filters might block them. Researchers will compare 736 newborns who get the filter to those who don't, t…

This study looks at whether giving platelet transfusions only when levels are very low can help extremely premature babies (born at 23-26 weeks) survive without major bleeding. About 2,400 infants will be randomly assigned to a lower or higher transfusion trigger. The goal is to …

This study tests whether adding azithromycin to the standard antibiotic ampicillin can reduce serious health problems in newborns when a mother's water breaks early (between 34 and 37 weeks). About 311 women with a single pregnancy will receive either ampicillin alone or ampicill…

This study tests whether real-time video consultations with a neonatologist (a baby doctor) can improve outcomes for at-risk newborns delivered in community hospitals. About 947 newborns and their doctors will take part. The main goal is to see if this approach lowers the number …

This study tests whether removing cow's milk protein from the diet (via mother's diet or special formula) works better than the drug omeprazole for treating gastroesophageal reflux disease (GERD) in infants under 1 year old. About 96 babies with GERD will be randomly assigned to …

This study is testing whether following a Mediterranean diet during pregnancy can reduce the chance of children developing allergies by age 2. Researchers are enrolling 276 healthy pregnant women (ages 20-35) who are at risk of having a baby with allergies. Participants receive p…

This study tests a behavioral program called MomMA for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms and related mood issues during pregnancy and after birth. Researchers will compare it to usual care in 80 participants to see if it is acceptable an…

This study tests whether pairing pregnant survivors of intimate partner violence (IPV) with a trained doula can reduce abuse and coercion compared to standard advocacy. Researchers will enroll 250 participants in the Pittsburgh area and track experiences of physical, sexual, emot…

This study looks at whether swaddling (wrapping snugly) or nesting (creating a cozy boundary) can lower pain and stress in newborns who need breathing support. About 100 babies born after 35 weeks will be watched for heart rate, oxygen levels, and stress signs. A painless saliva …

This study tracks babies born at exactly 22 weeks of pregnancy across about 45 UK hospitals. Researchers will collect information from medical records—without names or dates—to see how these extremely premature babies fare and what care they receive. The goal is to fill a huge kn…

This study is testing whether a new wireless skin sensor system can safely and accurately monitor the heart rate, breathing, oxygen levels, and temperature of healthy newborns right after birth. 600 babies will wear both the wireless sensors and standard wired monitors for the fi…

This study tracks lung ultrasound images over time in preterm babies born before 32 weeks who need surfactant for breathing problems. Researchers want to see if the way surfactant is given changes how the lungs look on ultrasound. About 68 babies will take part to help doctors le…

This observational study will measure levels of a protein called phoenixin-14 in the blood of 84 newborn babies—some born to mothers with diabetes and some healthy. Researchers will also check the babies' hearts with ultrasound to see if higher protein levels are linked to heart …

This study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…

This study looks back at medical records of 648 women who had heavy bleeding after a C-section. Researchers want to see how often the drug tranexamic acid (TXA) was given over the years, and whether more use led to better outcomes like less blood loss or fewer transfusions. The g…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu or COVID-19 raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to provide clear evidence to help…