Medical College Of Wisconsin

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This early study tests whether the drug theophylline can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. Thirty infants will receive one or two doses of theophylline within 18 hours of birth. The main goal is …

This was a small, early-phase study designed to test the safety and feasibility of a cancer vaccine (SV-BR-1-GM) combined with the immunotherapy drug pembrolizumab (Keytruda) in patients with solid tumors that had spread to the brain or spinal cord lining. The trial planned to en…

This study tests a newer, highly precise radiation technique for men with high-risk prostate cancer. The treatment delivers a strong dose to the pelvic lymph nodes while boosting radiation to the prostate itself. Researchers want to see if this approach controls the cancer better…

This study looks at whether measuring blood pressure inside the heart's left upper chamber during a procedure for atrial fibrillation (an irregular heartbeat) can spot patients with hidden heart failure. If the pressure is high, patients get a heart failure checkup and medication…

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This study tests whether a probiotic called Lactobacillus plantarum 299v (Lp299v) can improve blood vessel function in people with Long COVID (PASC). The trial includes 80 adults who had COVID-19 30-180 days ago and have ongoing symptoms. Participants take either the probiotic or…

This study tests whether a probiotic drink called Lp299v (found in GoodBelly StraightShot) can reverse age-related stiffening of blood vessels in healthy adults aged 50 to 99. The 20 participants will take the drink daily and have their blood vessel function measured. It is a sma…

This study tests a combination of four drugs (isatuximab, pomalidomide, elotuzumab, and dexamethasone) in people with multiple myeloma that has come back or stopped responding to at least two prior treatments. The goal is to see how well the drug combo controls the cancer. The st…

This study looks at the best time to start medication for gestational diabetes during pregnancy. About 416 pregnant women with the condition are randomly assigned to start medicine when 20% or 40% of their blood sugar readings are too high. The goal is to see which approach leads…

This phase 2 trial tests whether a probiotic called Lactiplantibacillus plantarum (Lp299v) can reduce inflammation and help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. The study includes 60 participants aged 3 to 45 who were diagnos…

This phase 2 trial tests whether a combination of isatuximab, lenalidomide, and dexamethasone can eliminate minimal residual disease (MRD) in multiple myeloma patients who still have detectable cancer cells after a stem cell transplant. About 30 adults will receive the drug combo…

This study tests whether a lower-dose combination of two drugs (PTCy and ruxolitinib) can prevent graft-versus-host disease (GVHD) in older adults receiving a stem cell transplant for blood cancer. About 56 participants will receive the treatment and be monitored for survival wit…

This early-phase study is testing whether giving a shorter, more intense course of radiation before surgery is safe for people with head and neck cancer. The trial involves 12 adults with HPV-negative, surgically removable tumors. The main goal is to see if this condensed radiati…

This study tests giving a short course of focused radiation before breast cancer surgery, using MRI for precise planning. The goal is to treat a smaller area of the breast and possibly reduce side effects. About 39 women with early-stage breast cancer will receive five radiation …

This study tests a program that helps HIV-positive men who have sex with men build social support to stay in medical care. One hundred participants in St. Petersburg, Russia, will either get individual counseling or that plus group sessions to boost resilience and connect with su…

This early-stage trial tests a gene therapy for adults with severe hemophilia A who have or had Factor VIII inhibitors. Doctors take the patient's own blood stem cells, add a gene that makes Factor VIII, and return the modified cells. The goal is to see if this approach is safe a…

This early-stage study tests an oral drug called gallium maltolate in 26 people whose glioblastoma (a severe brain cancer) has returned after prior treatment. The main goal is to find a safe dose and see if it can slow tumor growth. Participants take the drug by mouth and are mon…

This study tests whether intensive blood pressure treatment after childbirth can improve women's long-term heart health. Researchers will enroll 60 women who had high blood pressure during pregnancy and give them nifedipine to keep their BP below 140/90 mmHg. The goal is to see i…

This study tests whether giving blood pressure medication to women after childbirth can prevent hospital readmissions and reduce severe high blood pressure. About 300 women with preeclampsia will either receive standard care or start blood pressure drugs like labetalol or nifedip…

This study tests whether taking a probiotic supplement can reduce inflammation in children and teens (ages 5-17) recently diagnosed with type 1 diabetes. The goal is to see if changing gut bacteria can slow the disease's progression. Participants receive either a probiotic or a p…

This early-phase trial tests a new drug, loncastuximab tesirine, combined with a standard chemotherapy regimen (DA-EPOCH-R) in 11 adults with aggressive B-cell lymphomas. The main goal is to find the safest dose and check for side effects. It is not yet known if this combination …

This phase 2 trial is testing whether adding the immunotherapy drug cemiplimab (Libtayo) to standard chemotherapy can eliminate more cancer before surgery in people with high-risk or locally advanced breast cancer. The study enrolls 36 participants with either hormone receptor-po…

This study was designed to test a new thermo-acoustic imaging device that may help diagnose fatty liver disease without invasive procedures. It would have compared the device's accuracy to standard MRI scans in adults aged 18-70 with known or suspected fatty liver. However, the s…

This study tests whether providing fresh meals, health coaching, and education to high-risk pregnant women can reduce the chance of developing gestational diabetes, high blood pressure, or preeclampsia. 69 women in Milwaukee are randomly assigned to either receive the program or …

This small pilot study is testing whether a daily low dose of naltrexone (4.5 mg) can reduce central neuropathic pain and improve quality of life in 10 adults with traumatic spinal cord injury. Participants take the drug for 12 weeks, and researchers measure pain scores and daily…

This study tests whether a 3-week outpatient rehab program can reduce long-lasting symptoms of traumatic brain injury (TBI) and related conditions like PTSD and depression in 416 veterans and first responders. Participants will complete surveys, and some will also give blood samp…

This study tests whether a mild electrical current applied to the brain (tDCS) during speech therapy can improve language recovery in people with aphasia after a stroke. Two hundred adults with language problems from left-brain damage will receive either real or fake stimulation …

This study looks at whether floating in a special tank that reduces outside stimulation can help people with posttraumatic stress disorder (PTSD). About 30 adults with PTSD will take part. Researchers will measure changes in PTSD symptoms, stress, mood, and pain before and after …

This study looked at whether taking a probiotic supplement for 8 weeks could reduce inflammation and pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker of inflammation (C-react…

This study tests a 4-month community program called Men Moving Forward for African-American men who have finished prostate cancer treatment. The program includes twice-weekly sessions to help participants eat more fruits and vegetables, cut down on red meat, and increase physical…

This study aimed to see if adding blood flow restriction (BFR) therapy to standard physical therapy improves recovery after surgery for a tibial plateau fracture. It planned to enroll adults who had that surgery and measure knee function, muscle size, and movement over one year. …

This study is looking for 50 adults with soft tissue sarcoma to see if a blood test can detect tumor DNA (ctDNA) as well as a standard tissue biopsy. Currently, doctors need to take a piece of the tumor to diagnose and monitor sarcoma, which can be risky and hard to do. By compar…

This study aimed to see if two advanced imaging modes, TXI and RDI, built into standard colonoscopy equipment, could make removing large colon polyps faster and safer. The trial was planned for adults with polyps 20 mm or larger, but it was withdrawn before any participants were …

This study aims to find biomarkers that identify people at risk of a disproportionate drop in resting metabolic rate during and after weight loss. Sixty participants with obesity will follow a 6-month meal replacement program with lifestyle advice. Their resting metabolic rate an…

This study aims to find the best MRI settings for the MR-linac, a machine that combines MRI and radiation therapy. Researchers will test different scan parameters in cancer patients and healthy volunteers to get clearer, more accurate images. The goal is to improve radiation ther…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This pilot study explores how Iyengar Yoga affects the brain and body in older adults with prolonged grief disorder. About 68 participants will take yoga classes or join a social group for comparison. Researchers will measure changes in brain activity, grief symptoms, and natural…

This study looks at how the kidneys work differently in people whose blood pressure is sensitive to salt. Researchers will measure kidney oxygen levels and chemical changes in 70 adults with mild high blood pressure after low- and high-salt diets. The goal is to find new ways to …

This study tests whether using ultrasound to guide a bone marrow biopsy is better than the usual method of feeling for landmarks on the body. The researchers will compare pain, sample quality, and procedure time in 100 hospitalized adults. If ultrasound helps, it could lead to mo…

This study looks at whether realistic simulation training can help caregivers of children with tracheostomies (with or without home ventilators) handle emergencies better. About 60 caregivers will be split into two groups: one gets the simulation training, the other gets standard…

This study looks at whether advanced MRI scans can predict how well Optune therapy works in people with newly diagnosed glioblastoma, a type of brain cancer. Researchers will compare standard and advanced MRI in 60 participants to see which better forecasts survival at six months…

This study looks at how genetic testing affects stress and anxiety in women with breast cancer or at high risk. Researchers will survey 164 participants before and after genetic counseling to track changes in worry and health anxiety. The goal is to learn how to better support pa…

This study aimed to develop better diagnostic tests and a device (external pressure on the throat) for patients with pharyngeal reflux, where stomach contents reach the throat. It planned to include adults with GERD and throat symptoms. However, the study was withdrawn before enr…

This study looks at how testosterone therapy changes heart and metabolic health in transgender boys and men aged 12 to 30. Researchers will measure blood vessel function, blood pressure, and body composition over one year. The goal is to understand any risks and whether starting …