Medical College Of Wisconsin

This early-stage study is testing the safety of a much shorter, more intense course of radiation given before surgery for certain head and neck cancers. The goal is to see if delivering the radiation in just 5 to 10 visits over 1-2 weeks is as safe as the standard 30-visit schedu…

This study is testing whether a combination of four drugs is safe and effective for adults with multiple myeloma that has come back or stopped responding to at least two prior treatments. The goal is to see if this four-drug mix works better than similar combinations with fewer d…

This is an early safety study testing a new gene therapy approach for adults with severe hemophilia A, a serious bleeding disorder. Researchers will collect a patient's own blood stem cells, genetically modify them in a lab to produce the missing clotting factor inside platelets,…

This early-stage trial aims to find a safe and tolerable dose of a new drug, loncastuximab tesirine, when combined with a standard chemotherapy regimen (DA-EPOCH-R). It is for adults with aggressive types of B-cell lymphoma, including Burkitt lymphoma, who have not yet received m…

This study aims to see if more intensive blood pressure control in the year after a pregnancy complicated by high blood pressure can improve a woman's long-term heart health. It will involve 60 women who have just given birth, with half receiving more intensive treatment and half…

This study is testing a new approach for treating early-stage breast cancer. It gives a short, focused course of radiation to the tumor area *before* surgery, instead of after. The goal is to see if this method is safe and effective, and if using an MRI scan for planning helps ta…

This study is testing whether a lower-dose combination of medications can safely prevent graft-versus-host disease (GVHD) in older adults receiving stem cell transplants for blood cancers. GVHD occurs when donor immune cells attack the patient's body, and current prevention metho…

This study is testing whether a daily probiotic supplement can help control type 1 diabetes in children and teens recently diagnosed. Researchers want to see if changing gut bacteria can reduce harmful inflammation and potentially slow the loss of the body's insulin-producing cel…

This study aims to find the best time to start medication for pregnant women with gestational diabetes. Researchers are comparing whether starting medication when 20% of blood sugar readings are high is better than waiting until 40% are high. The goal is to reduce pregnancy compl…

This study is testing whether a daily probiotic supplement can help people recently diagnosed with type 1 diabetes. Researchers want to see if the probiotic reduces harmful inflammation in the body and helps preserve the body's own ability to produce some insulin. The study invol…

This is an early-stage study testing a new oral medication called gallium maltolate for adults with glioblastoma, a serious brain cancer, that has come back after standard treatments. The main goal is to find a safe dose and see if the drug shows any signs of helping control the …

This study aims to find out if giving blood pressure medication to women with preeclampsia right after they give birth helps prevent dangerous high blood pressure and reduces their need to return to the hospital. It will involve 300 women who have recently delivered and have been…

This study is testing whether giving higher, more targeted doses of radiation along with chemotherapy can better control inoperable pancreatic cancer. It is for people whose cancer has not spread and who have already completed several months of chemotherapy. The goal is to see if…

This study aimed to see if two special camera modes on a standard colonoscopy system could help doctors remove large colon polyps more effectively. The tools were meant to make the polyp's edges clearer to see and to spot blood vessels that might cause bleeding after removal. The…

This study is testing whether a combination of three drugs (isatuximab, lenalidomide, and dexamethasone) can eliminate tiny amounts of remaining cancer cells in multiple myeloma patients who have already received a stem cell transplant. The trial will enroll 30 adults who still s…

This study is testing if adding an immunotherapy drug called cemiplimab to standard chemotherapy before surgery works better for certain high-risk breast cancers. It will involve 36 women with locally advanced breast cancer that tests positive for specific markers. The main goal …

This study is testing whether a group counseling program helps HIV-positive men who have sex with men in St. Petersburg, Russia, stay engaged with their medical care. 100 men who are not currently seeing a doctor regularly will be randomly assigned to receive either standard coun…

This study is testing a 4-month lifestyle program designed specifically for African American men who have completed treatment for prostate cancer. The program involves twice-weekly sessions focused on healthy eating and physical activity, following American Cancer Society guideli…

This study aimed to test a new type of ultrasound device for detecting and measuring fat in the liver. Researchers planned to compare the device's accuracy to the current standard method, an MRI scan. The trial was withdrawn before any participants were enrolled.

This study compares two methods for performing bone marrow biopsies, a common test for blood cancers and disorders. Researchers are testing whether using an ultrasound machine to guide the needle improves the quality of the tissue sample and reduces patient pain compared to the s…

This study aimed to create better tests to diagnose when stomach acid backs up into the throat (pharyngeal reflux). Researchers planned to study patients with this condition to understand how a valve in the throat fails. They also wanted to test if gentle external pressure on the…

This study is testing whether a probiotic supplement can reduce body-wide inflammation in teenagers who have chronic pain and a higher body weight. Researchers want to see if lowering inflammation also leads to less pain and better daily function. The study involves 39 teens aged…

This study is testing whether a therapy called 'floatation-REST' can help ease symptoms of PTSD. Thirty adults with PTSD will float in a quiet, dark, shallow saltwater pool to see if it reduces their stress, anxiety, and depression. The researchers are measuring how participants …

This study is exploring whether a 10-week Iyengar yoga program can help researchers understand the brain and body changes in people with prolonged grief disorder. It involves 68 adults over 40 who have been grieving for more than 6 months. The goal is to see if yoga can ease grie…

This study aimed to see if adding blood flow restriction therapy to standard physical therapy helps people recover better from a serious knee fracture surgery. It planned to compare two groups of adults over one year, measuring their leg strength, muscle size, and how well they c…

This study is testing whether a mild, painless electrical current applied to the scalp (called tDCS) can boost the benefits of speech therapy for people who have trouble speaking after a stroke. About 200 participants will receive either real or fake stimulation during therapy se…

This study aims to understand how genetic testing affects stress and anxiety levels in people with or at high risk for breast cancer. Researchers will measure stress using questionnaires before testing and several times after patients receive their results. The goal is to gather …

This study aims to understand why some people experience a significant slowdown in their metabolism after losing weight, which can make it hard to keep the weight off. Researchers will measure hormones and other body signals in 60 adults with obesity before, during, and after a w…

This study aims to collect and analyze information about how breast cancer is found, treated, and what the outcomes are for transgender and gender-diverse people. Researchers are looking at past medical records from 125 people to better understand the unique experiences and chall…

This study aims to determine if advanced MRI scans can predict which patients with newly diagnosed glioblastoma (an aggressive brain cancer) will respond best to Optune therapy. Researchers will compare standard and advanced MRI images from 60 patients receiving Optune plus chemo…

This study aims to improve how surgeons monitor hand function during awake brain tumor surgery. Researchers will test a special data glove and different stimulation settings to measure hand strength and movement more precisely. The goal is to help surgeons remove as much tumor as…

This study aims to develop better MRI scanning methods specifically for radiation therapy in cancer patients. Researchers will work with 295 participants, including both cancer patients and healthy volunteers, to improve image quality and test new treatment planning software. The…

This study aims to understand why some people's blood pressure rises with high salt intake while others' does not. Researchers will have 70 participants with varying blood pressure levels follow high-salt and low-salt diets for two weeks each. They will use special MRI scans and …

This study aims to understand how testosterone therapy affects heart and metabolic health in transgender boys and men. Researchers will follow 90 participants, including transgender individuals starting testosterone and cisgender individuals for comparison, for one year. The main…

This study is testing whether realistic simulation training helps caregivers better manage emergencies at home for children who need a tracheostomy (a breathing tube in the neck). Caregivers are randomly assigned to receive either high-tech mannequin-based training, simpler doll-…