Medical College Of Wisconsin

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. About 30 adults aged 18 to 45 who are at least 6 months post-transplant will receive the vaccine. Researchers will measure their antibody levels over 2 years and compare t…

This study tests a three-drug combination (isatuximab, lenalidomide, and dexamethasone) in 30 adults with multiple myeloma who still have tiny amounts of cancer cells in their bone marrow after a stem cell transplant. The goal is to see if the treatment can make those leftover ce…

This study tests whether a probiotic called Lp299v can improve blood vessel function in people with long COVID (PASC). The trial involves 80 adults who had COVID-19 in the past 30-180 days and now have long COVID symptoms. Researchers will measure blood vessel health using ultras…

This study tests whether a daily probiotic supplement can reduce inflammation in children and teens newly diagnosed with type 1 diabetes. Researchers believe that changes in gut bacteria may worsen the disease. Participants take either the probiotic or a placebo for several month…

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The main goal is to see how many pat…

This early-stage trial tests an oral drug called gallium maltolate in 26 people whose glioblastoma has returned after standard treatment. The main goal is to find a safe dose and see if it can slow tumor growth. Participants take the drug by mouth and have regular scans to track …

This early-phase study tests a new gene therapy for adults with severe hemophilia A who have or had inhibitors. Doctors take the patient's own stem cells, add a gene that makes Factor VIII (a clotting protein), and return the cells. The goal is to see if this is safe and if the m…

This study tests a combination of four drugs (isatuximab, pomalidomide, elotuzumab, and dexamethasone) in people with multiple myeloma that has come back or stopped responding to at least two prior treatments. The goal is to see how well the drug combo controls the cancer. About …

This study tests whether a lower-dose combination of two drugs (PTCy and ruxolitinib) can safely prevent graft-versus-host disease (GVHD) in older adults receiving a stem cell transplant for blood cancer. About 56 participants will receive the treatment and be monitored for survi…

This study tests whether intensive blood pressure control right after childbirth can improve long-term heart health in women who had high blood pressure during pregnancy. About 60 women will be randomly assigned to standard or intensive treatment and followed for 12 months. The g…

This study looks at whether giving blood pressure medication to women who had preeclampsia during pregnancy can lower their risk of being readmitted to the hospital after giving birth. About 300 new mothers with high blood pressure will be randomly assigned to receive treatment o…

This study tests whether a daily probiotic supplement called Lp299v can improve blood vessel health in healthy adults aged 50 to 99. Researchers will measure how well blood vessels expand and relax, and look at changes in gut bacteria. The goal is to see if targeting the gut can …

This study tests whether the drug cemiplimab can help shrink or eliminate breast cancer before surgery in people with high-risk or locally advanced luminal or triple-negative breast cancer. 36 participants will receive the drug and then have their tumor tissue checked for a compl…

This early-phase trial tests a new drug, loncastuximab tesirine, added to a standard chemotherapy regimen (DA-EPOCH-R) for people with previously untreated aggressive B-cell lymphomas. The main goal is to find the safest dose and see how well the combination is tolerated. The stu…

This study tests whether a condensed, shorter course of radiation given before surgery is safe for people with head and neck cancer. It involves 12 adults with HPV-negative, advanced but removable tumors. The main goal is to see if this approach causes severe side effects or prev…

This study tests whether a program that helps HIV-positive men who have sex with men build supportive friendships and community connections can improve their medical care attendance and overall health. One hundred participants in St. Petersburg, Russia, will receive either standa…

This study looks at the best time to start medication for pregnant women with gestational diabetes. About 416 women will be randomly assigned to begin treatment when either 20% or 40% of their blood sugar readings are too high. The goal is to see which approach leads to fewer hea…

This study tests giving a short course of focused radiation to the breast tumor before surgery, using MRI for precise planning. The goal is to treat a smaller area of breast tissue and possibly reduce side effects. About 39 women with early-stage breast cancer will receive radiat…

This study tests whether a probiotic called Lactiplantibacillus plantarum 299v can reduce inflammation and help preserve the body's ability to produce insulin in people recently diagnosed with type 1 diabetes. About 60 participants aged 3 to 45 will take the probiotic or a placeb…

This study was designed to see if a new device that uses sound waves (thermo-acoustic imaging) can accurately measure fat in the liver. It planned to compare the device's results with standard MRI scans in adults with or suspected of having non-alcoholic fatty liver disease. The …

This study tests whether a 3-week outpatient rehab program can reduce lasting symptoms of traumatic brain injury (TBI) and related conditions in 416 veterans and first responders. Participants will answer surveys about their symptoms and life quality, and some will also give bloo…

This small pilot study is testing whether a daily low dose of naltrexone (4.5 mg) can reduce central neuropathic pain and improve quality of life in people with traumatic spinal cord injury. Ten adults with chronic pain will take the drug for 12 weeks, with no comparison group. T…

This study explores whether floating in a special tank that reduces outside noise and light can help adults with posttraumatic stress disorder (PTSD). Thirty people with PTSD will try floating and report changes in symptoms like stress, anxiety, depression, and pain. The goal is …

This study tests whether a mild electrical current applied to the scalp, combined with speech therapy, can help people with aphasia (trouble speaking or understanding language) after a stroke. About 200 adults aged 18–85 with language problems from left-brain damage will receive …

This study tests a 4-month community program called Men Moving Forward for African-American men who have finished prostate cancer treatment. Participants attend two sessions each week to improve their diet and physical activity. The goal is to help them build muscle, lose fat, an…

This study looked at whether taking a probiotic supplement for 8 weeks could lower inflammation and ease pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker for inflammation and…

This study looks at how the kidneys work differently in people whose blood pressure is sensitive to salt. Researchers will measure kidney oxygen levels and metabolism in 70 adults with elevated or stage 1 high blood pressure after low- and high-salt diets. The goal is to uncover …

This study tests whether realistic simulation training helps caregivers of children with tracheostomies (with or without home ventilators) manage emergencies. About 60 caregivers will be trained using high-tech simulations to see if it reduces hospital readmissions and ER visits.…

This study aims to find the best settings for MRI scans used during radiation therapy for cancer. Researchers will test different scan parameters on both cancer patients and healthy volunteers to get clearer, more accurate images. The goal is to improve how doctors see tumors and…

This study was designed to find better ways to diagnose when stomach contents flow back into the throat (pharyngeal reflux) in people with GERD. Researchers planned to measure muscle function in the throat and test if pressing on the voice box could stop reflux. However, the stud…

This study aims to find biological markers in the blood that can identify people whose metabolism slows down more than expected during weight loss. Researchers will measure resting metabolic rate and hormone levels in 60 adults with obesity over 18 months. The goal is to understa…

This study looks at how testosterone therapy affects the heart and metabolism in transgender boys and men aged 12 to 30. Researchers will measure changes in blood vessel function, blood pressure, and body composition over one year. The goal is to understand any health risks and w…

This study looks at whether two special imaging tools, TXI and RDI, can help doctors remove large colon polyps more safely and quickly. These tools are already approved and used in standard colonoscopies. The study involves adults with large polyps and will compare the new imagin…

This study looks at whether advanced MRI scans can better predict how patients with newly diagnosed glioblastoma respond to Optune therapy compared to standard MRI. About 60 participants will be followed to see how many are alive at six months and one year. The goal is to improve…

This study looks at how genetic testing for breast cancer affects a person's stress and anxiety levels. Researchers will measure stress before and after testing in 164 women who either have breast cancer or are at high risk. The goal is to help doctors provide better support duri…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse (TGD) adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal i…

This study compares two methods for guiding bone marrow biopsies: the standard approach using touch to find the right spot, and a newer method using ultrasound imaging. Researchers want to see if ultrasound leads to less pain, better samples, and smoother procedures. About 100 ad…

This study looks at how Iyengar Yoga affects the brain and body in older adults with prolonged grief disorder (PGD). About 68 people aged 40 and older who have been grieving for more than 6 months will take part. Researchers will measure changes in brain activity and natural chem…

This study aimed to see if adding blood flow restriction therapy to standard physical therapy helps people recover more muscle strength and function after surgery for a broken knee (tibial plateau fracture). It planned to follow adults for one year after surgery, measuring knee s…