Could a probiotic help long COVID Patients' blood vessels?

NCT ID NCT05227170

Ongoing Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a probiotic called Lactobacillus plantarum 299v (Lp299v) can improve blood vessel function in people with Long COVID (PASC). The trial includes 80 adults who had COVID-19 30-180 days ago and have ongoing symptoms. Participants take either the probiotic or a placebo capsule for a period, and researchers measure changes in blood vessel health and inflammation markers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactobacillus plantarum 299v (a probiotic)
What this could lead to: If it works, this could point toward a simple probiotic supplement to help improve blood vessel health and reduce inflammation in people with Long COVID.
What could go wrong: This is a small, early-stage trial with no phase designation, so results may not be conclusive. The probiotic is already in food products, but its effect on Long COVID symptoms is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 Inflammation long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Locations

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

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