Medical College Of Wisconsin

This study tested a one-time treatment using the patient's own immune cells, engineered to target and kill myeloma cells. It involved 40 adults with multiple myeloma who had a weak response to a stem cell transplant and ongoing maintenance therapy. The goal was to see if this cel…

This study tested a new way to do stem cell transplants for people with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The approach used a half-matched donor (haploidentical) to help more patients find a donor. The main goal was to see …

This study tested a blend of six Chinese herbs, called Anti-tumor B, in 30 people with squamous cell cancer of the mouth. The goal was to see if the herbs could slow cancer cell growth before standard treatment. Participants took the herbal agent for a short time, and researchers…

This study tested a bone marrow transplant from a half-matched donor (haploidentical) in 95 children and adults with severe sickle cell disease. The goal was to see if the transplant could help patients live without major complications for two years. The approach used a reduced-i…

This study tested a new version of the chemotherapy drug melphalan (EVOMELA) combined with fludarabine and total body irradiation before a half-matched (haploidentical) stem cell transplant in 43 adults with blood cancers like multiple myeloma. The goal was to see if this approac…

This study tested a shorter, higher-dose radiation course given before surgery for soft tissue sarcoma in the arms, legs, or chest wall. Researchers wanted to see if this approach was safe, feasible, and effective at controlling the tumor. The study included 35 adults with locali…

This study tested a phone-based program for 100 African Americans aged 50 and older with poorly controlled type 2 diabetes. The program combined diabetes education and skills training with help resolving social needs like food or housing. Results aim to show whether this approach…

This study tested a combination of three drugs (bevacizumab, atezolizumab, and rucaparib) in 30 people with endometrial cancer that had come back or continued to grow after prior treatment. The goal was to see if the drug mix could shrink tumors or slow the cancer. The trial is c…

This small pilot study tested a new order of treatment for people with brain metastases (cancer that spread to the brain). Instead of the usual surgery first, patients received focused radiation (gamma knife) before surgery. The goal was to see if this approach could better contr…

This study looked at whether taking a probiotic supplement can improve blood vessel function and reduce inflammation in people with heart disease or type 2 diabetes. Researchers measured blood markers, gut bacteria, and vessel health in 215 adults. The goal was to see if changing…

This study tested whether bringing together groups of friends who all have HIV can help them support each other to stay in medical care and take their medication. Over 300 people in St. Petersburg, Russia, took part. The approach aimed to improve viral load, clinic visits, and me…

This study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Participants received either diabetes education or extra support tailored to their caregiving challenges. The goal was to see if the p…

This study tested whether the drug tildrakizumab can help prevent graft-versus-host disease (GVHD) in people receiving a stem cell transplant for blood cancers. GVHD occurs when donor cells attack the patient's body. The trial included 51 adults with blood cancers like leukemia. …

This study tested a program to help young men who have sex with men (ages 17-24) use HIV self-testing and take PrEP, a daily pill that prevents HIV. The program provided information, motivation, and skills through online modules. The goal was to see if it increased HIV testing an…

This study tested a small, non-invasive device placed on the ear to see if it could reduce nausea in teenagers with functional gastrointestinal disorders. 109 teens took part; half received an active nerve stimulator and half received an inactive one. The goal was to measure chan…

This study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise capacity and blood vessel function in people with chronic heart failure. Ten adults with heart failure and signs of inflammation took either the probiotic or a pla…

This study tested whether mild electrical stimulation (tDCS) combined with speech therapy can help people with long-term language problems after a stroke. 25 adults with aphasia received both treatments and were tested on naming pictures and reading words. The goal was to see if …

This small pilot study tested whether a combination of gentle brain stimulation (called HD-tDCS) and computer-based memory exercises could improve thinking skills in people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main …

This study tested if giving fewer, higher-dose radiation sessions after surgery for head and neck cancer is safe. 18 adults with certain risk factors received 10, 8, or 5 treatments instead of the usual 30. The goal was to find the shortest schedule that doesn't cause severe side…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) could better control pain after heart surgery. 62 adults undergoing elective heart surgery were randomly assigned to receive either th…

This study tested a non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The treatment involves briefly restricting blood flow to the leg using a cuff, which may improve nerve and blood vessel function. The main goal was to see if it could increase…

This study tested a nerve-freezing technique (cryoanalgesia) during robot-assisted lung surgery to see if it reduces pain afterward. 33 adults having lung surgery were randomly assigned to receive the nerve block or not. Researchers measured pain scores and pain medication use fo…

This study tested a non-invasive nerve stimulator placed on the ear to reduce nausea and vomiting in 47 children and adults with cyclic vomiting syndrome. Participants used the device daily for up to 6 weeks, and researchers tracked symptom severity using standard scales. The goa…

This study tested whether an animated video sent by text message helps parents of babies with health problems communicate better with their doctors during prenatal visits. 48 pregnant people took part, with some receiving the video and others just links to clinic webpages. Resear…

This study explored how non-caloric artificial sweeteners (like those in diet sodas) might affect body fat, metabolism, and blood sugar control in young people aged 5-17 with type 1 diabetes. Researchers measured body composition, blood markers, and diet habits in 21 participants…

This study looked at how the inner ear reacts to sound during and after cochlear implant surgery. Researchers used CT scans and hearing tests to see where the implant's electrode sits and how much natural hearing is preserved. The goal was to learn more about how well the implant…

This study looked at 150 women who had a rare but serious heart condition called peripartum cardiomyopathy, which caused a life-threatening drop in blood flow (cardiogenic shock) around the time of childbirth. Researchers collected information from medical records and follow-ups …

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs met, like food or housing. 50 people took part to see if the program was practical and could improve blood sugar, blood pressure, and quality of life. The goal w…

This study looked at how blood moves through leg muscles in people who have had a stroke compared to healthy adults. Researchers used ultrasound to measure blood flow during passive leg movement and active muscle contractions. The goal was to understand why stroke survivors often…

This study looked at cancer patients with diarrhea who tested positive for C. diff bacteria but negative for the toxin that usually causes illness. Half received an antibiotic (vancomycin) and half received a placebo for 14 days. The goal was to see how the treatment affected bac…

This study looked at brain tissue from 20 glioblastoma patients who had received tumor treatment fields (TTFields) therapy. Researchers examined the tissue after death to count active and inactive cancer cells. The goal was to understand how TTFields work at a cellular level, not…

This study looked at whether giving CPR instructions over the phone before help arrives increases the number of bystanders who perform CPR. Researchers studied 274 adults who had a cardiac arrest outside of a hospital. They compared CPR rates before and after starting a phone ins…

This study looked at 20 women who had radiation and chemotherapy for node-positive breast cancer years ago. Researchers used cardiac MRI to check for heart damage and see if it relates to the radiation dose. The goal was to better understand safe radiation levels, not to test a n…

This study tested whether a deeper self-swab (5 cm) collects better cell samples for anal cancer screening than a shallower one (3 cm). Fifty adults at higher risk for anal cancer tried both depths. The goal was to see which method better captures cells from the area most likely …

This study looked at whether an artificial intelligence (AI) device can improve how anesthesiology residents learn to use ultrasound for regional anesthesia. Twenty residents with no prior experience in this technique used the AI tool during training. The researchers measured the…