Medical College Of Wisconsin

This study tested whether giving a single high dose of vitamin B12 (5 grams) to 20 adults with septic shock is feasible and safe. Patients received either vitamin B12 or a placebo (saline) alongside standard care. The main goal was to see if the study procedures could be complete…

This study tested a treatment called anti-BCMA CAR T-cell therapy in 40 adults with multiple myeloma whose disease did not respond well enough to a stem cell transplant and maintenance therapy. The goal was to see if this one-time cell therapy could help more patients achieve a c…

This study tested a phone-based program for 100 African Americans aged 50+ with poorly controlled type 2 diabetes. The program combined diabetes education and help with social needs like food or housing. Results aim to show if this approach improves blood sugar control and qualit…

This study tested whether giving fewer, higher-dose radiation sessions after surgery for head and neck cancer is safe. Eighteen adults with certain risk factors received one of three shortened radiation schedules. The goal was to find the shortest course that does not cause sever…

This study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This phase 2 trial tested a half-matched (haploidentical) bone marrow transplant in 95 children and adults with severe sickle cell disease. The goal was to see if this approach could help patients live without major complications for two years. Participants received a reduced-int…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This phase 2 trial tested a combination of three drugs—rucaparib, bevacizumab, and atezolizumab—in 30 people with recurrent or progressive endometrial cancer that had not responded to prior treatments. The goal was to see if the combination could shrink tumors or slow the cancer'…

This study tested a stem cell transplant from a half-matched family donor for people with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal was to see if this approach could improve survival one year after the transplant. The tria…

This study tested a blend of six Chinese herbs, called Anti-tumor B, in 30 people with squamous cell cancer of the mouth. The goal was to see if the herbs could slow cancer cell growth before standard treatment. Results focused on changes in a cell growth marker called Ki-67.

This study tested whether taking a daily probiotic drink called Goodbelly for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if the probiotic made …

This pilot study tested whether giving gamma knife radiation before surgery for brain metastases is safe and feasible. Eleven adults with 1 to 4 brain tumors took part. The goal was to see how many patients could have surgery after radiation and how many had no visible tumor left…

This study tested a new version of the chemotherapy drug melphalan (EVOMELA) combined with fludarabine and total body irradiation before a half-matched (haploidentical) stem cell transplant in 43 adults with blood cancers like multiple myeloma. The goal was to see if this approac…

This study tested whether bringing together groups of friends who all have HIV helps them support each other to stay in medical care and take their medications. Over 300 people in St. Petersburg, Russia, took part. The approach uses everyday friendships to encourage regular docto…

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs, like food and housing, while also providing lifestyle coaching. Fifty participants received one-on-one sessions and a device to track blood sugar and blood pres…

This pilot study tested a shorter course of radiation (hypofractionated) given before surgery for soft tissue sarcoma of the arm, leg, or chest wall. The goal was to see if this approach is safe, feasible, and controls the tumor locally. Thirty-five adults with localized sarcoma …

This study tested whether the drug tildrakizumab could help prevent graft-versus-host disease (GVHD) in 51 adults receiving a stem cell transplant for blood cancers. GVHD is a serious complication where donor cells attack the patient's body. The goal was to see if adding tildraki…

This study tested a program to help young men (ages 17-24) who have sex with men use HIV self-testing and PrEP (a daily pill to prevent HIV). 118 participants joined the pilot study. The program provided information, motivation, and skills to encourage HIV testing and PrEP use. T…

This study tested a simple, non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The procedure involves inflating a blood pressure cuff on the affected leg to briefly stop blood flow, then releasing it, repeated several times. Researchers measured …

This pilot study tested whether combining a gentle brain stimulation technique called HD-tDCS with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main goal was to see i…

This study tested freezing the nerves between the ribs during robot-assisted lung surgery to see if it reduces pain and the need for painkillers afterward. 33 adults having lung surgery were randomly assigned to get the nerve freeze or standard pain medicine. Researchers tracked …

This pilot study tested a small device that stimulates nerves in the ear to help people with cyclic vomiting syndrome, a condition causing repeated bouts of severe nausea and vomiting. Forty-seven children and adults used the device either during an episode or daily for six weeks…

This study tested a non-invasive nerve stimulator placed on the outer ear to see if it could reduce nausea in 109 teenagers with functional gastrointestinal disorders. Half received the active device, half a sham (inactive) version, for four weeks. The goal was to measure changes…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigne…

This study tested whether a gentle electrical current applied to the scalp (tDCS) during speech therapy could help people with chronic aphasia—a language disorder after stroke—recover their ability to name objects and read words. Twenty-five adults with long-term aphasia received…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This study looked at how blood moves through leg muscles in people who have had a stroke compared to healthy adults. Researchers used gentle leg movements and muscle contractions to measure blood flow. The goal was to learn more about why stroke survivors often have reduced exerc…

This study looked at whether giving CPR instructions over the phone before help arrives increases the number of bystanders who perform CPR. Researchers tracked 274 adults who had a cardiac arrest outside the hospital. The goal was to see if simple instructions could save more liv…

This study looked at 20 women who had radiation therapy for node-positive breast cancer years earlier. Researchers used cardiac MRI to check heart function and see if radiation dose levels were linked to heart damage. The goal was to better understand safe radiation limits to pro…

This study looked at brain tissue from 20 glioblastoma patients who had received Tumor Treating Fields (TTFields) therapy. Researchers examined the tissue after the patients died to see how the treatment affected tumor cells. The goal was to find patterns that could help doctors …

This study tested whether an animated video sent by text message helps parents prepare for conversations with their doctor during prenatal visits for fetal anomalies. 48 pregnant adults were randomly assigned to receive either the video or links to clinic webpages. Researchers th…

This study looked at how non-caloric artificial sweeteners (like those in diet drinks) affect body composition, metabolism, and blood sugar control in 21 youth aged 5-17 with type 1 diabetes. Researchers measured body fat and muscle using special scans and tested blood for marker…

This study tested whether an artificial intelligence (AI) device could help teach anesthesiology residents how to perform ultrasound-guided regional anesthesia. Twenty residents with no prior experience in this area used the AI tool and then filled out a questionnaire about their…

This study looked at 150 women who had a rare heart condition called peripartum cardiomyopathy (heart failure around childbirth) that led to cardiogenic shock (the heart can't pump enough blood). Researchers observed their long-term health and the treatments they received. The go…

This study tested whether a deeper self-collected swab (5 cm) collects better cell samples from the anal canal compared to a shallower one (3 cm). Fifty adults at higher risk for anal cancer participated. The goal was to see which depth gives a more useful sample for screening, w…

This completed study looked at how the inner ear responds to sound during and after cochlear implant surgery in 88 participants. Researchers used a noninvasive test called electrocochleography to measure electrical activity in the cochlea. The goal was to see if these measurement…