New hope for aggressive lymphoma: experimental combo tested in early trial

NCT ID NCT05270057

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 26 times

Summary

This early-phase trial tests a new drug, loncastuximab tesirine, added to a standard chemotherapy regimen (DA-EPOCH-R) for people with previously untreated aggressive B-cell lymphomas. The main goal is to find the safest dose and see how well the combination is tolerated. The study involves 11 adults with specific lymphoma types, including Burkitt lymphoma and high-grade B-cell lymphoma.

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Contacts and locations

Locations

  • Froedtert Hospital & the Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States

  • University of Wisconsin School of Medicine and Public Health

    Madison, Wisconsin, 53705, United States

Conditions

Explore the condition pages connected to this study.