Tiny margin, big difference? new trial tests radiation precision for brain tumors
NCT ID NCT06857006
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using a 0mm or 2mm margin around brain metastases during radiosurgery leads to better tumor control with fewer side effects. Radiosurgery delivers a high dose of radiation to kill tumors. The trial will enroll 180 adults with brain metastases up to 4 cm in size. By comparing the two margin sizes, researchers hope to find the best balance between killing cancer and protecting healthy brain tissue.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiosurgery (focused radiation to kill tumors)
What this could lead to
If successful, this could show that a smaller radiation margin (0mm) works just as well as a larger one (2mm) for controlling brain metastases, potentially reducing side effects.
What could go wrong
This is a phase 2 trial with 180 participants, so results are still preliminary. The optimal margin may depend on tumor size or location, and individual outcomes may vary.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BRAIN METASTASES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University of Alabama at Birmingham (UAB) Hazelrig-Salter Radiation Oncology Center
RECRUITINGBirmingham, Alabama, 35249, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact