BRAIN METASTASES

This phase 2 trial tests the drug pembrolizumab in 101 adults with cancer that has spread to the brain or spinal cord. The goal is to see if the drug can shrink or stabilize these tumors. Participants receive pembrolizumab along with standard imaging and sometimes radiation. The …

This study tests whether adding the drug tucatinib to standard therapy (trastuzumab/pertuzumab or T-DM1) can prevent new or worsening brain metastases in people with advanced HER2+ breast cancer. About 48 participants who have stable disease elsewhere but a new brain tumor will r…

This was a small, early-phase study designed to test the safety and feasibility of a cancer vaccine (SV-BR-1-GM) combined with the immunotherapy drug pembrolizumab (Keytruda) in patients with solid tumors that had spread to the brain or spinal cord lining. The trial planned to en…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. It involves 46 adults with cancer that has spread to the brain. The goal is to improve tumor control without causing serious side e…

This study tests whether adding focused radiation (stereotactic radiosurgery) to a combination of targeted drugs (binimetinib and encorafenib) and an immunotherapy (pembrolizumab) can better control melanoma that has spread to the brain. It includes 10 adults with a specific gene…

This trial looks at the best time to give radiotherapy for brain metastases that can be surgically removed. It compares giving radiation before surgery, during surgery, or after surgery. The goal is to see which timing best prevents the tumor from coming back. About 90 adults wit…

This phase 2 trial is testing a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus two cycles of chemotherapy as a first treatment for people with advanced lung cancer that has spread to the brain. The study aims to see if this approach can control the cancer …

This early-stage study tests a drug called GDC-0084 given alongside radiation therapy for people whose cancer has spread to the brain and has a specific genetic mutation (PI3K). The main goal is to find the safest dose of the drug and see if the combination helps shrink tumors. O…

This study tests the drug lorlatinib in people with a specific type of lung cancer (ALK-positive) that has spread to the brain or the lining of the brain and spinal cord. The goal is to see how well the drug shrinks these brain tumors. About 41 participants will take lorlatinib o…

This phase 2 trial is testing whether giving focused radiation before surgery for brain metastases can delay tumor regrowth better than standard care. About 49 adults with solid tumors (not lymphoma or germ cell) and at least one brain metastasis will receive three daily doses of…

This study tests a drug called QBS72S in 21 adults with breast or lung cancer that has spread to the brain. The drug is given once a month through an IV. The main goal is to see if it shrinks brain tumors. The trial is active but not recruiting new participants.

This study tests whether the immunotherapy drug nivolumab, alone or combined with ipilimumab, can shrink melanoma tumors that have spread to the brain. About 76 adults with stage IV melanoma and at least one brain metastasis will receive treatment. The main goal is to see how man…

This early-phase study tests whether combining two cancer drugs (cabozantinib and nivolumab) with precise radiation is safe for people with kidney cancer that has spread to the brain. Only 2 participants were enrolled, and the main goal is to see if they can tolerate the treatmen…

This phase 3 trial tests a new radiation device called Gamma Tile, which is placed directly in the brain during surgery to deliver radiation immediately, versus standard radiation given weeks later. The study involves 230 adults with newly diagnosed brain metastases who need one …

This study tests whether adding precise radiation (stereotactic radiosurgery) to standard drug therapy can better control brain metastases in people with non-small cell lung cancer. Participants have brain tumors that remain after 3-6 months of a targeted drug. The goal is to see…

This small pilot study tests whether a special PET scan called Axumin can help doctors tell the difference between real tumor growth and treatment-related inflammation (pseudo-progression) in people with brain metastases who are on immunotherapy. The study enrolled 3 adults with …

This study tests whether an extra MRI scan, taken later than usual, can better tell the difference between a growing tumor and harmless radiation scar in people with brain metastases who have had radiosurgery. Twenty-five adults with solid tumors (except small cell lung cancer or…

This study is testing a new type of PET/MRI scan to see if it can tell the difference between a tumor growing back and radiation damage (called radionecrosis) in people who have had brain radiation for cancer. Both conditions look similar on regular scans, so doctors often need s…

This early-phase study is testing whether a special PET scan (68Ga-PSMA-11) can effectively show tumor activity in people with high-grade gliomas or brain metastases. About 11 adults whose tumors are at least 1 cm and who are already scheduled for a biopsy or surgery will receive…

This study tests a modified whole brain radiation technique that avoids a specific area of the brain called the corpus callosum genu, which is important for memory and thinking. The goal is to see if this approach helps preserve cognitive function in people with brain metastases …

This trial planned to compare a second round of whole brain radiotherapy plus supportive care against supportive care alone for people with brain metastases that returned after initial treatment. It was designed for patients who could not have surgery or precise radiation. Howeve…

This early-phase study tests giving a precise dose of radiation to brain tumors before surgical removal, rather than after. The goal is to protect healthy brain tissue and possibly eliminate the need for additional radiation after surgery. About 25 adults with brain metastases (t…

This study looks at two ways to give radiation to brain tumors in people who are also receiving immunotherapy for cancers like lung, breast, kidney, or melanoma. The standard approach gives one high dose of radiation, while the experimental approach gives smaller doses over sever…

This study looks at whether a ketogenic (high-fat, low-carb) diet is practical and beneficial for 24 adults with brain metastases who are scheduled for radiosurgery. Participants will follow either a ketogenic diet or a standard healthy diet for 16 weeks. Researchers will track d…

This study looks at how precise radiation (stereotactic radiosurgery) affects memory and thinking in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will take part to find the safest radiation dose and measure any decline in memory over 4 m…

This study uses special MRI scans to see how radiation treatment affects the brain's white matter and thinking skills in people with cancer that has spread to the brain. Researchers will follow 15 patients to find early signs of memory or concentration problems. The goal is to be…

This study tracks 80 patients with brain tumors (metastases or meningiomas) who receive stereotactic radiosurgery. Researchers use memory tests and quality-of-life questionnaires before treatment and every 3 months for a year to see if and how brain function changes. By comparing…

This study looks at two types of radiation for people with 5 to 30 brain tumors that have spread from other cancers. One group gets focused radiation (SRS) alone, the other gets whole-brain radiation plus SRS. The main goal is to see which approach better protects memory and thin…

This study follows 110 people with brain metastases who are receiving either focused or whole-brain radiation. Researchers use advanced MRI scans and memory tests before treatment and for two years after to see if the scans can predict thinking and memory problems. The goal is to…

This observational study looks back at 700 patients from 15 hospitals in 2 countries to compare local treatments like surgery and radiation for brain metastases that spread from colorectal cancer. Researchers will track how long patients live and how long it takes for brain tumor…

This study reviews medical records from 230 adults with stomach or esophagus cancer that spread to the brain. Researchers want to see which local treatments (like surgery or radiation) worked best and how long patients lived. The goal is to gather information to help doctors make…

This study looks at whether a computer model can analyze routine brain MRI scans to predict if a lung cancer that has spread to the brain has certain genetic changes (EGFR or ALK). The goal is to see if this noninvasive method can replace the need for a brain tumor biopsy to guid…