BRAIN METASTASES

This study tests a drug called QBS72S in 21 adults with advanced breast or lung cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors and help people live longer without the cancer getting worse. Participants must be 18 or older and in fairly…

This study tests whether adding targeted radiation (stereotactic radiosurgery) to a three-drug combination (binimetinib, encorafenib, pembrolizumab) helps control melanoma that has spread to the brain. It includes 10 adults with a specific gene mutation (BRAF V600). The main goal…

This study tests a new way to deliver radiation to people with brain tumors that have spread from other cancers. Instead of waiting weeks after surgery for standard radiation, some patients receive a special tile (GammaTile) placed directly in the surgical area during the operati…

This study tests whether the immunotherapy drug nivolumab, alone or combined with ipilimumab, can shrink melanoma that has spread to the brain. About 76 adults with stage IV melanoma and at least one brain metastasis will receive these treatments. The main goal is to see how many…

This study tests giving focused radiation before surgery to remove brain metastases (tumors that spread from other cancers). The goal is to see if this approach delays tumor regrowth compared to standard care. About 49 adults with solid tumors and at least one brain metastasis wi…

This early-phase study tested whether combining two drugs (cabozantinib and nivolumab) with radiation therapy is safe for people with kidney cancer that has spread to the brain. Only 2 participants were enrolled, and the main goal was to see if they could tolerate the treatment w…

This study looks at whether adding stereotactic radiotherapy (precise radiation) can help control brain metastases that remain after initial drug therapy in people with non-small cell lung cancer. About 202 participants will be randomly assigned to receive either standard drug tr…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This early-phase study tests the safety of combining an experimental drug (GDC-0084) with radiation therapy for people whose cancer has spread to the brain or its lining. It includes 21 adults with specific genetic mutations (PIK3CA). The goal is to find the safest dose and see i…

This study is for people with advanced HER2+ breast cancer whose cancer has spread to the brain but is stable elsewhere. Participants will continue their current treatment and add the drug tucatinib to see if it can delay or prevent new brain tumors. The goal is to improve contro…

This study tests the drug lorlatinib in people with a specific type of lung cancer (ALK-positive) that has spread to the brain or the lining of the spinal cord. The goal is to see how well the drug shrinks tumors in the brain and controls the disease. About 41 adults will take pa…

This study is testing a precise form of radiation called stereotactic radiosurgery for patients who have six or more brain tumors that have spread from cancer elsewhere in the body. The main goal is to see if this targeted approach causes less memory loss and thinking problems th…

This early-phase study tests whether a special PET scan (68Ga-PSMA-11) can detect tumor activity in people with high-grade glioma or brain metastases. Eleven adults with suspected or confirmed tumors will receive the scan before a planned biopsy or surgery. The goal is to measure…

This study tests a new type of PET/MRI scan to tell the difference between a brain tumor growing back and a side effect of radiation called radionecrosis. Both conditions look very similar on regular scans and cause similar symptoms, so doctors often need surgery to find out whic…

This study tests whether an extra MRI scan, taken later than usual, can better tell apart tumor regrowth from radiation damage in people with brain metastases who had radiosurgery. About 25 adults with a history of treated brain tumors will get this special MRI, and results will …

This early-phase trial tests whether giving focused radiation (radiosurgery) to a brain tumor before surgical removal helps protect healthy brain tissue and may eliminate the need for radiation after surgery. About 25 adults with brain metastases (tumors that spread from other ca…

This study was designed for patients with cancer that spread to the brain and came back after initial radiation. It aimed to see if a second round of whole brain radiation could help them stay independent longer compared to just supportive care. However, the study was withdrawn b…

This study reviews medical records from 230 adults across 15 hospitals in 2 countries to understand how brain metastases from stomach and esophageal cancers are treated. The goal is to see which local treatments (like surgery or radiation) work best and how long patients live aft…

This study looks at whether stereotactic radiosurgery (a precise type of radiation) for brain tumors causes thinking or memory problems. About 80 adults with brain metastases or benign meningiomas will take memory tests and quality-of-life surveys before and after treatment. Rese…

This study follows 110 people with brain metastases who receive either focused or whole-brain radiation. Researchers use advanced MRI scans and thinking tests before treatment and for two years after to see how the brain changes. The goal is to find early signs of cognitive decli…

This study looks at two types of radiation therapy for people with 5 to 30 brain tumors that have spread from other cancers. One group gets focused radiation (SRS) alone, the other gets whole-brain radiation plus SRS. The goal is to see which approach better preserves memory and …

This study looks at past medical records and brain scans from 380 adults with non-small cell lung cancer that has spread to the brain. Researchers are testing whether a computer model can predict certain genetic changes (EGFR or ALK) from routine MRI images, which could help guid…